Evidence map›Paper›PMID 39674881›Full record

ReviewEuropean journal of clinical investigation2024

The emerging role of Fusobacteria in carcinogenesis.

Raisha J Gibbs, Adam C Chambers, Darryl J Hill

Abstract readReview
In one paragraph

Review in European journal of clinical investigation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Metaplasia Enables Stomach Colonization bybioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Review
  5. The emerging role of Fusobacteria in carcinogenesis.European journal of clinical investigation · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Raisha J GibbsUniversity of Bristol, Bristol, UK.ORCID https://orcid.org/0009-0000-7300-7949
Adam C ChambersUniversity of Bristol, Bristol, UK.ORCID https://orcid.org/0000-0002-3215-0535
Darryl J HillUniversity of Bristol, Bristol, UK.ORCID https://orcid.org/0000-0002-5743-5078

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Fusobacterium genus comprises Gram-negative, obligate anaerobic bacteria that typically reside in the periodontium of the oral cavity, gastrointestinal tract, and female genital tract. The association of Fusobacterial spp. with colorectal tumours is widely accepted, with further evidence that this pathogen may also be implicated in the development of other malignancies. Fusobacterial spp. influence malignant cell behaviours and the tumour microenvironment in various ways, which can be related to the multiple surface adhesins expressed. These adhesins include Fap2 (fibroblast-activated protein 2), CpbF (CEACAM binding protein of Fusobacteria), FadA (Fusobacterium adhesin A) and FomA (Fusobacterial outer membrane protein A). This review outlines the influence of Fusobacteria in promoting cancer initiation and progression, impacts of therapeutic outcomes and discusses potential therapeutic interventions where appropriate.

Indexed as

CarcinogenesisAdhesins, BacterialColorectal NeoplasmsFusobacteriumFusobacterium InfectionsHumansNeoplasmsTumor MicroenvironmentAdhesins, BacterialcancercarcinogenesisCEACAMcolorectalFusobacteriasignalling

Identifiers

PMID39674881
PMCPMC11646295

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.