Evidence map›Paper›PMID 39674581›Full record

ArticleJournal of medical genetics2025

Validation of the NCCN/Yale criteria for the identification of

Benjamin A Lerner, Mar Giner-Calabuig, Cassidy Carraway, Marcy Richardson, Karl Krahn, Lisa Susswein, Sarah M Nielsen, Rachid Karam, Rosa M Xicola, Xavier Llor

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Benjamin A Lerner *Department of Medicine, Yale University, New Haven, Connecticut, USA.
Mar Giner-Calabuig *Department of Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Cassidy CarrawayAmbry Genetics Corporation, Aliso Viejo, California, USA.
Marcy RichardsonClinical Research, Ambry Genetics, Aliso Viejo, California, USA.
Karl KrahnGeneDx, Stamford, Connecticut, USA.
Lisa SussweinGeneDx, Stamford, Connecticut, USA.
Sarah M NielsenLabcorp Genetics, Burlington, North Carolina, USA.
Rachid KaramAmbry Genetics, Aliso Viejo, California, USA.ORCID 0000-0002-5645-498X
Rosa M XicolaGenetics, Yale University, New Haven, CT, USA.
Xavier LlorDepartment of Medicine, Yale School of Medicine, New Haven, Connecticut, USA xavier.llor@yale.edu.ORCID 0000-0002-6259-185X

Funding

TRAINING PROGRAM IN INVESTIGATIVE GASTROENTEROLOGYT32DK007017 · NIDDK · YALE UNIVERSITY · PI Fred Sanford Gorelick, Liza Konnikova · 1986 to 2026
$7.1M
NIDDK NIH HHS T32 DK007017
6 · The paper itself

Abstract

backgroundDiffuse gastric and lobular breast cancer (LBC) syndrome is an autosomal-dominant syndrome characterised by early-onset diffuse gastric cancer and LBC most often caused by germline pathogenic variants (PVs) in

methodsWe aggregated demographic and clinical data of all

resultsData on 708 probands and their 4318 family members were included in the analysis. In this cohort, the sensitivities for detecting

conclusionIn a large cohort of

Indexed as

Antigens, CDBreast NeoplasmsCadherinsCarcinoma, LobularGenetic TestingStomach NeoplasmsAdultFemaleGenetic Predisposition to DiseaseGerm-Line MutationHeterozygoteHumansMaleMiddle AgedAntigens, CDCadherinsCDH1 protein, humanGastrointestinal DiseasesGenetic Carrier Screening

Identifiers

PMID39674581
PMCPMC11916899

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.