ArticleToxicological sciences : an official journal of the Society of Toxicology2025
Simulated burn pit smoke condensates cause sustained impact on human airway epithelial cells.
Arunava Ghosh, Keith L Rogers, Samuel C Gallant, Stephanie A Brocke, Adam M Speen, Yong Ho Kim, M Ian Gilmour, Scott H Randell, Ilona Jaspers
Abstract read
In one paragraphArticle in Toxicological sciences : an official journal of the Society of Toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
Arunava GhoshCenter for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.ORCID 0000-0001-9550-1366 Keith L RogersCurriculum in Toxicology and Environmental Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7310, United States.
Samuel C GallantMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Stephanie A BrockeCurriculum in Toxicology and Environmental Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7310, United States.
Adam M SpeenCenter for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Yong Ho KimPublic Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, United States.ORCID 0000-0001-7527-0134 M Ian GilmourPublic Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, United States.
Scott H RandellMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Ilona JaspersCenter for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.ORCID 0000-0001-8728-0305 Funding
Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Scott H Randell · 2004 to 2026
$26.5MTOXICOLOGYT32ES007126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ILONA JASPERS, Bernard E. Weissman · 1985 to 2026
$13.0MToxicity testing of fresh and photochemically aged burn pit smoke emissionsR03ES032539 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KIM, YONG HO · 2021 to 2022
$156kCystic Fibrosis Foundation BOUCHE19R0Department of Defense's FY17 Peer Reviewed Medical Research W81XWH-18-1-0731Environmental Protection Agency's intramural research programMarsico Lung InstituteNational Institute of Health DK065988NIDDK NIH HHS P30 DK065988NIEHS NIH HHS R03 ES032539NIEHS NIH HHS R03ES032539NIEHS NIH HHS T32 ES007126Office of Research and DevelopmentTissue Procurement and Cell Culture Core
6 · The paper itselfAbstract
Inhalation of smoke from burn pits during military deployment is associated with several adverse pulmonary outcomes. We exposed human airway epithelial cells to smoke condensates from burn pit waste materials. Single and repeated exposure to condensates triggered unique and common responses in terms of gene expression that were sustained through the recovery phase. Source material and combustion condition influenced the outcome. Intensified response in female donor cells indicated a determining role of biological sex. The observations indicate a lasting impact of burn pit smoke exposure on epithelial gene expression, potentially contributing to disease pathogenesis.
Indexed as
Epithelial CellsRespiratory MucosaSmokeSmoke Inhalation InjuryFemaleHumansInhalation ExposureMaleOpen Waste BurningSmokeburn pit wastehuman airway epithelial cellsRNA sequencingsex differences
Identifiers
PMID39673801
PMCPMC11879058
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