ArticleBJS open2024
Postoperative complications after breast cancer surgery and effect on recurrence and survival: population-based cohort study.
Article in BJS open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Erector spinae plane block (ESPB) versus paravertebral plane block (PVB) in managing post-operative pain in breast cancer patients: a systematic review and meta-analysis.World journal of surgical oncology · 2026Pooled it
- Clinical and economic impact of incisional negative pressure wound therapy in breast surgery: meta-analysis.The British journal of surgery · 2026Pooled it
- Case-mix-adjusted benchmarking of long-term breast cancer-specific mortality: Insights from a nationwide Swedish registry.Breast (Edinburgh, Scotland) · 2026Article
- Age-specific breast cancer incidence by subtype, TNM stage and screening status in Sweden 2008-2019 estimated with multiple imputation.International journal of cancer · 2026Article
- Upper-limb symptom clusters and their associations with surgical complications among breast cancer survivors: A cross-sectional study.Asia-Pacific journal of oncology nursing · 2025Article
- Major systemic infection following breast cancer surgery and oncological outcomes.The British journal of surgery · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundThere is conflicting evidence regarding whether postoperative complications after breast cancer surgery are associated with worse oncological outcome. This study aimed to assess the risk of systemic breast cancer recurrence after surgical site infection and also the impact of surgical site infection on locoregional recurrence, breast cancer-specific survival and overall survival.
methodsThis nationwide cohort study included patients who underwent surgery for primary breast cancer in Sweden between January 2008 and September 2019. The study cohort was identified in the Breast Cancer Database Sweden 3.0, a database linking the National Breast Cancer Quality Register to national population-based healthcare registers held by the National Board of Health and Welfare and Statistics Sweden. The primary exposure was surgical site infection within 90 days from surgery, and the primary outcome was systemic recurrence of breast cancer. Secondary outcomes included locoregional recurrence, overall survival and breast cancer-specific survival. Multivariable Cox regression analysis was performed to assess the association between exposure, predictors and outcomes.
resultsOf 82 102 patients included in the study, 15.7% experienced a surgical site infection within 90 days of surgery. Surgical site infection was not significantly associated with systemic recurrence, locoregional recurrence or breast cancer-specific survival after adjustment for confounding variables. Surgical site infection was significantly associated with worse overall survival, but the significant association disappeared in a sensitivity analysis excluding all patients with any kind of malignancy before breast cancer diagnosis.
conclusionSurgical site infection after breast cancer surgery does not significantly increase the risk of systemic recurrence. All possible actions should nevertheless be taken to reduce complication rates.
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