ArticleLiver international : official journal of the International Association for the Study of the Liver2025
Hepatic Steatosis and Fibrosis, Cardiorespiratory Fitness, and Metabolic Mediators in the Community.
Victor V Florea, Priya Gajjar, Shi Huang, Jingxian Tang, Shilin Zhao, Megan Davenport, Michael Y Mi, Madeleine Haff, Xiaoyu Zhang, Patricia E Miller and 6 more
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In one paragraphArticle in Liver international : official journal of the International Association for the Study of the Liver, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
16 authors.
Victor V FloreaDepartment of Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, Massachusetts, USA.ORCID 0009-0006-8903-7951 Priya GajjarCardiovascular Medicine Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Shi HuangVanderbilt Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jingxian TangDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Shilin ZhaoVanderbilt Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Megan DavenportCardiovascular Medicine Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Michael Y MiDivision of Cardiovascular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID 0000-0001-8031-8948 Madeleine HaffSection of Gastroenterology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Xiaoyu ZhangDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Patricia E MillerDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0002-0141-717X Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Gregory D LewisCardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-8108-8240 Ravi V ShahVanderbilt Translational and Clinical Research Center, Cardiology Division, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-4471-7156 Michelle T LongSection of Gastroenterology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.ORCID 0000-0001-6131-3981 Matthew NayorCardiovascular Medicine Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.ORCID 0000-0002-6993-9396 Funding
FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8MProteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF SpectrumR01HL131029 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Gregory Dyer Lewis, Matthew G. Nayor · 2016 to 2026
$7.7MMetabolic Responses to an Oral Mixed Meal Tolerance Test: Intra-individual changes, correlates, and prognostic significanceR01HL156975 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI NAYOR, MATTHEW G. · 2021 to 2025
$3.3MIdentifying clinical and genetic correlates of hepatic fibrosis from fatty liver disease in the communityK23DK113252 · NIDDK · BOSTON MEDICAL CENTER · PI LONG, MICHELLE T · 2018 to 2022
$944kMixed meal tolerance test elicited metabolite responses as novel markers of cardiometabolic riskK23HL171855 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Michael Mi · 2024 to 2026
$572kTHE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–American Heart AssociationClinical and Translational Science Institute, Boston UniversityDoris Duke Charitable FoundationEchosensGilead SciencesNHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS K23 HL171855NHLBI NIH HHS N01 HC025195NHLBI NIH HHS R01 HL131029NHLBI NIH HHS R01 HL156975NIDDK NIH HHS K23 DK113252School of Medicine, Boston University
6 · The paper itselfAbstract
BACKGROUND AND
aimsIndividuals with steatotic liver disease (SLD) are at high cardiovascular disease (CVD) risk, but approaches to characterise and mitigate this risk are limited. By investigating relations, and shared metabolic pathways, of hepatic steatosis/fibrosis and cardiorespiratory fitness (CRF), we sought to identify new avenues for CVD risk reduction in SLD.
methodsIn Framingham Heart Study (FHS) participants (N = 2722, age 54 ± 9 years, 53% women), vibration-controlled transient elastography (VCTE) was performed between 2016-2019 to assess hepatic steatosis (continuous attenuation parameter [CAP]) and fibrosis (liver fibrosis measure [LSM]). Concurrently, participants underwent maximum effort cardiopulmonary exercise testing (CPET), and metabolomic profiling (201 circulating metabolites) was performed in a subsample (N = 1268).
resultsMean BMI was 28.0 ± 5.3, 27% had hepatic steatosis, 7.6% had fibrosis, and peak oxygen uptake (VO
conclusionsHepatic steatosis and fibrosis are associated with CRF impairment in the community, and these relations are partly mediated by pathways of altered lipid metabolism and general cardiometabolic risk.
Indexed as
Cardiorespiratory FitnessLiver CirrhosisAdultAgedCardiovascular DiseasesElasticity Imaging TechniquesExercise TestFatty LiverFemaleHumansMaleMetabolomicsMiddle AgedNon-alcoholic Fatty Liver DiseaseOxygen Consumptioncardiopulmonary exercise testingmetabolic dysfunction‐associated steatotic liver diseasemetabolismmetabolomicspeak oxygen uptake
Identifiers
PMID39673712
PMCPMC11649011
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