Evidence map›Paper›PMID 39673660›Full record

ArticleMolecular neurobiology2025

Light Treatment Ameliorates Sub-chronic MK-801-Induced Cognitive Deficits in Mice Through Up-regulating BDNF/p-CREB/p-ERK Signaling Pathway.

Keke Cui, Yiying Zhou, Lizhi Zhang, Yudong Ying, Yan Xue, Xiaoqin Zhang, Qinwen Wang, Haowei Shen, Wenhua Zhou, Feng Gao and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Keke Cui *Zhejiang Key Laboratory of Pathophysiology, Basic Medical Sciences, Health Science Center, Ningbo University, 818 Fenghua Rd, Ningbo, 315211, Zhejiang, China.
Yiying Zhou *Key Laboratory of Addiction Research of Zhejiang Province, Kang Ning Hospital, Ningbo, 315010, China.
Lizhi ZhangZhejiang Key Laboratory of Pathophysiology, Basic Medical Sciences, Health Science Center, Ningbo University, 818 Fenghua Rd, Ningbo, 315211, Zhejiang, China.
Yudong YingZhejiang Key Laboratory of Pathophysiology, Basic Medical Sciences, Health Science Center, Ningbo University, 818 Fenghua Rd, Ningbo, 315211, Zhejiang, China.
Yan XueZhejiang Key Laboratory of Pathophysiology, Basic Medical Sciences, Health Science Center, Ningbo University, 818 Fenghua Rd, Ningbo, 315211, Zhejiang, China.
Xiaoqin ZhangKey Laboratory of Addiction Research of Zhejiang Province, Kang Ning Hospital, Ningbo, 315010, China.
Qinwen WangZhejiang Key Laboratory of Pathophysiology, Basic Medical Sciences, Health Science Center, Ningbo University, 818 Fenghua Rd, Ningbo, 315211, Zhejiang, China.
Haowei ShenKey Laboratory of Addiction Research of Zhejiang Province, Kang Ning Hospital, Ningbo, 315010, China.
Wenhua ZhouKey Laboratory of Addiction Research of Zhejiang Province, Kang Ning Hospital, Ningbo, 315010, China.
Feng GaoThe Affiliated People's Hospital of Ningbo University, Ningbo, 315100, China. rmgaofeng@nbu.edu.cn.
Zhengchun WangThe Affiliated People's Hospital of Ningbo University, Ningbo, 315100, China. wangzhengchun@nbu.edu.cn.ORCID http://orcid.org/0000-0002-5140-051X

Funding

Innovative Research Group Project of the National Natural Science Foundation of China 31800874International Cooperation Project of Ningbo City 2022S027Key Research and Development Program of Zhejiang Province 2024C03101Natural Science Foundation of Zhejiang Province LY21C090001
6 · The paper itself

Abstract

Cognitive impairment associated with schizophrenia (CIAS) is considered a core symptom of the illness, yet effective treatments remain limited. Light plays an important role in regulating cognitive functions. However, the potential of light treatment (LT) to improve CIAS remains unknown. The current study aimed to investigate the efficacy of LT on CIAS and explore the underlying molecular mechanisms in a CIAS animal model. The CIAS group and the control group were sub-chronically administered MK-801 and saline, respectively. Concurrently, the LT/CIAS group, consisting of CIAS mice, received LT exposure (3000 Lux, 2 h/day, for 3 weeks). Results showed a significant enhancement in cognitive performance among LT/CIAS mice, as evidenced by improvements in the novel object recognition (NOR) test, novel location recognition (NLR) test, and Morris water maze (MWM) compared to the CIAS group. Remarkably, these beneficial effects of LT persisted for over 4 weeks after the termination of LT. Furthermore, Golgi-cox staining unveiled an increased dendritic spine density and enhanced morphological complexity in hippocampal CA1 pyramidal neurons following 3 weeks of LT. Subsequent investigations revealed elevated levels of brain-derived neurotrophic factor (BDNF) and heightened phosphorylation of cAMP response element-binding phosphorylation protein (p-CREB) in the hippocampus of the LT/CIAS group compared to the CIAS group. Moreover, LT elevated the phosphorylated extracellular signal-regulated kinase (p-ERK) in the hippocampus of the LT/CIAS group relative to the CIAS group. In conclusion, the current study demonstrates that long-term LT effectively ameliorated sub-chronic MK-801-induced cognitive deficits in mice, and the altered dendritic spine density and morphology of CA1 pyramidal neurons were rescued in the LT/CIAS group, potentially through the up-regulation of the BDNF/p-CREB/p-ERK signaling pathway in LT/CIAS mice.

Indexed as

Brain-Derived Neurotrophic FactorCognitive DysfunctionCyclic AMP Response Element-Binding ProteinDizocilpine MaleateMAP Kinase Signaling SystemUp-RegulationAnimalsDendritic SpinesMaleMiceMice, Inbred C57BLPhosphorylationSignal TransductionBdnf protein, mouseBrain-Derived Neurotrophic FactorCyclic AMP Response Element-Binding ProteinDizocilpine MaleateBDNF/p-CREB/p-ERKCognition impairmentsDendritic spinesLight treatmentMK-801

Identifiers

PMID39673660

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.