Evidence map›Paper›PMID 39673652›Full record

ReviewNeurochemical research2024

Function of Brain-Derived Neurotrophic Factor in the Vestibular-Cochlear System.

Bin Zhang, Su-Lan Chen, Xin Teng, Qi Han, Tong Wu, Zhen Yang, Yin Liu, Ke Xiang, Li Sun

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neurochemical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Frontiers in aging neuroscience · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bin ZhangChangchun University of Chinese Medicine, Changchun, Jilin Province, 130017, China.
Su-Lan ChenChangchun University of Chinese Medicine, Changchun, Jilin Province, 130017, China.
Xin TengChangchun University of Chinese Medicine, Changchun, Jilin Province, 130017, China.
Qi HanDepartment of Geriatrics, Jilin Provincial Academy of Traditional Chinese Medicine, No.6426 of Freie Road, Changchun, Jilin Province, 130021, China.
Tong WuDepartment of Geriatrics, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, Jiangsu Province, 215101, China.
Zhen YangScientific Research Center, Jilin Provincial Academy of Traditional Chinese Medicine, Changchun, Jilin Province, 130021, China.
Yin LiuDepartment of Geriatrics, Jilin Provincial Academy of Traditional Chinese Medicine, No.6426 of Freie Road, Changchun, Jilin Province, 130021, China.
Ke XiangDepartment of Geriatrics, Jilin Provincial Academy of Traditional Chinese Medicine, No.6426 of Freie Road, Changchun, Jilin Province, 130021, China.
Li SunDepartment of Geriatrics, Jilin Provincial Academy of Traditional Chinese Medicine, No.6426 of Freie Road, Changchun, Jilin Province, 130021, China. sunlissll77@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain-derived neurotrophic factor (BDNF) is essential for the development and functioning of the vestibular system. BDNF promotes the growth, differentiation, and synaptic plasticity of vestibular neurons, ensuring their normal operation and maintenance. According to research, BDNF is pivotal during vestibular compensation, aiding in the recovery of neuron function by remodeling the spontaneous resting potentials of damaged vestibular neurons. Additionally, BDNF exhibits dose-dependent and age-dependent characteristics during vestibular system development, with its deficiencies leading to the degeneration of vestibular neurons. BDNF dynamically interacts with other neurotrophic factors, such as fibroblast growth factor-2 (FGF-2) and glial cell line-derived neurotrophic factor (GDNF), synergistically enhancing neuron survival and functionality. This review outline the function of BDNF in the vestibulocochlear system and explores its potential therapeutic applications, offering fresh perspectives and guidance for future research and treatment of vestibulocochlear system disorders.

Indexed as

Brain-Derived Neurotrophic FactorCochleaAnimalsHumansVestibule, LabyrinthBrain-Derived Neurotrophic FactorBrain-derived neurotrophic factor (BDNF)Neurotrophic factorsTherapeutic applicationsVestibular compensationVestibulocochlear system

Identifiers

PMID39673652

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.