Evidence map›Paper›PMID 39673460›Full record

ArticleProtein science : a publication of the Protein Society2025

Experimental recombining of repetitive motifs leads to large functional metallothioneins and demonstrates their modular evolvability potential.

Reinhard Dallinger, Veronika Pedrini-Martha, Maria Lucia Burdisso, Mercè Capdevila, Oscar Palacios, Ricard Albalat

Abstract read
In one paragraph

Article in Protein science : a publication of the Protein Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Reinhard DallingerInstitute of Zoology and Center of Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, Austria.
Veronika Pedrini-MarthaInstitute of Zoology and Center of Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, Austria.
Maria Lucia BurdissoDepartament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona (UB), Barcelona, Spain.
Mercè CapdevilaDepartament de Química, Facultat de Ciències, Universitat Autònoma de Barcelona (UAB), Cerdanyola del Vallès, Spain.
Oscar PalaciosDepartament de Química, Facultat de Ciències, Universitat Autònoma de Barcelona (UAB), Cerdanyola del Vallès, Spain.
Ricard AlbalatDepartament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona (UB), Barcelona, Spain.ORCID 0000-0003-0282-9595

Funding

Austrian Science Fund P33973-BEuropean Regional Development Fund/European UnionMICIU/AEI/10.13039/501100011033 PID2021-123258NB-I00Spanish Ministerio de Ciencia e Innovación BIO2015-67358-C2-2-P
6 · The paper itself

Abstract

Protein modularity is acknowledged for promoting the emergence of new protein variants via domain rearrangements. Metallothioneins (MTs) offer an excellent model system for experimentally examining the consequences of domain rearrangements due to the possibility to assess the functional properties of native and artificially created variants using spectroscopic methods and metal tolerance assays. In this study, we have investigated the functional properties of AbiMT4 from the snail Alinda biplicata (Gastropoda, Mollusca), a large MT comprising 10 putative β domains (β3

Indexed as

CadmiumMetallothioneinAmino Acid MotifsAnimalsEvolution, MolecularModels, MolecularProtein DomainsRepetitive Sequences, Amino AcidSnailsCadmiumMetallothioneinartificial variantsdomain repeat proteinsevolvabilitygastropoda/mollusca MTsprotein modularitysnail Alinda biplicata

Identifiers

PMID39673460
PMCPMC11645667

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.