Evidence map›Paper›PMID 39673402›Full record

ArticleJapanese journal of clinical oncology2025

Public assistance and survival equality in patients with EGFR mutation-positive lung cancer.

Kiyoaki Uryu, Yoshinori Imamura, Rai Shimoyama, Takahiro Mase, Yoshiaki Fujimura, Maki Hayashi, Megu Ohtaki, Keiko Otani, Makoto Hibino, Shigeto Horiuchi and 11 more

Erratum issuedAbstract read
In one paragraph

Article in Japanese journal of clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Kiyoaki UryuDepartment of Medical Oncology, Yao Tokushukai General Hospital, Yao-shi, Osaka 581-0011, Japan.ORCID 0009-0008-6068-1385
Yoshinori ImamuraCancer Care Promotion Center, University of Fukui Hospital, Yoshida-gun, Fukui 910-1193, Japan.
Rai ShimoyamaDepartment of General Surgery, Shonan Kamakura General Hospital, Kamakura-shi, Kanagawa 247-8533, Japan.ORCID 0000-0001-8601-0442
Takahiro MaseDepartment of Breast and Endocrine Surgery, Ogaki Tokushukai Hospital, Ogaki-shi, Gifu 503-0015, Japan.
Yoshiaki FujimuraTokushukai Information System Inc., Kita-ku, Osaka 530-0001, Japan.
Maki HayashiMirai Iryo Research Center Inc., Chiyoda-ku, Tokyo 102-0083, Japan.
Megu OhtakideCult Co., Ltd., Hatsukaichi-shi, Hiroshima 739-0413, Japan.
Keiko OtanideCult Co., Ltd., Hatsukaichi-shi, Hiroshima 739-0413, Japan.
Makoto HibinoDepartment of Respiratory Medicine, Shonan Fujisawa Tokushukai Hospital, Fujisawa-shi, Kanagawa 251-0041, Japan.
Shigeto HoriuchiDepartment of Respiratory Medicine, Shonan Fujisawa Tokushukai Hospital, Fujisawa-shi, Kanagawa 251-0041, Japan.
Tomoya FukuiDepartment of Respiratory Medicine, Shonan Kamakura General Hospital, Kamakura-shi, Kanagawa 247-8533, Japan.
Ryuta FukaiDepartment of General Thoracic Surgery, Shonan Kamakura General Hospital, Kamakura-shi, Kanagawa 247-8533, Japan.
Yusuke ChiharaDepartment of Respiratory Medicine, Uji Tokushukai Medical Center, Uji-shi, Kyoto 611-0041 Japan.
Akihiko IwaseDepartment of Respiratory Medicine, Chibanishi General Hospital, Matsudo-shi, Chiba 270-2251, Japan.
Noriko YamadaDepartment of General Thoracic Surgery, Chibanishi General Hospital, Matsudo-shi, Chiba 270-2251, Japan.
Yukihiro TamuraDepartment of General Internal Medicine, Oosumi Kanoya Hospital, Kanoya-shi, Kagoshima 893-0015, Japan.
Hiromasa HaradaDepartment of Respiratory Medicine, Yao Tokushukai General Hospital, Yao-shi, Osaka 581-0011, Japan.
Asuka TsuyaDepartment of Medical Oncology, Izumi City General Hospital, Izumi-shi, Osaka 594-0073, Japan.
Takafumi OkabeDepartment of Medical Oncology, Izumi City General Hospital, Izumi-shi, Osaka 594-0073, Japan.
Masahiro FukuokaDepartment of Medical Oncology, Izumi City General Hospital, Izumi-shi, Osaka 594-0073, Japan.
Hironobu MinamiDepartment of Medical Oncology and Hematology, Kobe University Graduate School of Medicine, Chuo-ku, Kobe-shi 650-0017, Japan.

Funding

Health Labour Sciences Research 23EA1036
6 · The paper itself

Abstract

backgroundDisparities in public assistance or the urbanization level of a residential region can affect cancer treatment outcomes. This study aimed to investigate whether these factors affect the overall survival (OS) of patients with epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC) using Tokushukai REAL World Data.

methodsWe analyzed the clinical data of consecutive patients with NSCLC receiving EGFR-tyrosine kinase inhibitors between April 2010 and March 2020 at 46 Tokushukai Medical Group hospitals in Japan. The patient's insurance coverage status was extracted from electronic medical records, and the urbanization level of residential regions was classified as megalopolis or other according to the secondary medical region. Univariate and multivariate Cox regression analyses were performed to examine the associations between OS and patient/tumor/treatment/socioeconomic-related factors.

resultsIn total, 758 patients (58.5% females) were included in the study; 41 patients (5.4%) received public assistance, and 442 patients (58.3%) were categorized under megalopolis in the secondary medical regions. In multivariate Cox regression analyses, there was no significant difference in the OS between non-recipients of public assistance and recipients [hazard ratio (HR) 1.084; 95% confidence intervals (CIs), 0.674-1.744]. There was also no significant difference in the OS between megalopolis and other regions in the secondary medical regions (HR 1.143; 95% CIs, 0.914-1.428).

conclusionsOur findings suggest that neither the use of public assistance nor the urbanization level in the residential region significantly impacts the prognosis of Japanese patients with EGFR mutation-positive NSCLC.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsAdultAgedAged, 80 and overErbB ReceptorsFemaleHumansJapanMaleMiddle AgedMutationSurvival RateEGFR protein, humanErbB Receptorsdisparityepidermal growth factor receptor tyrosine kinase inhibitornon-small cell lung cancerpublic assistanceurbanization level

Identifiers

PMID39673402
PMCPMC11882504

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.