SynthesisAllergy2025
Genome-Wide Association Study Reveals a Causal Relationship Between Allergic Rhinitis and Hazelnut Allergy.
Synthesis in Allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Integrative Drug-Target Causal Analysis, Single-Cell Sequencing and In-Vivo Validation for Dissecting Molecular Mechanisms Underlying Focal Epilepsy.CNS neuroscience & therapeutics · 2026Article
- The Immunogenetic Landscape of Allergic Rhinitis: from Cellular Effectors to Gene Regulation and Targeted Therapies.International journal of biological sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle is known about the genetics of food allergy (FA) to various allergens and the heterogeneity of FA in adults.
objectiveWe aimed to investigate genetic susceptibility to FA in an adult population and to assess the association between secondary FA and allergic rhinitis (AR).
methodsFA and allergen-specific FA were defined based on in-depth questionnaires and a previously published FA algorithm in the Lifelines. We performed a series of genome-wide association studies (GWAS) on FA and nine allergen-specific (e.g., hazelnut) FA in 21,353 adults in Lifelines. Single nucleotide polymorphisms (SNPs) (p < 1E-5) were replicated in a second independent set of 15,518 adults participating in the Lifelines followed by meta-analysis of the results of the two datasets. We subsequently investigated the causal relationship of AR to FA using Mendelian randomization (MR) analysis.
resultsWe observed co-occurrence of tree nuts and apple FA, with over 80% of this group also reporting AR. After meta-analysis, we identified one genome-wide significant locus near HLA-DPA1 associated with self-reported hazelnut allergy (hazelnutFA), of which the top SNP is rs5025825 (p = 2.51E-9, OR = 1.43). Two-sample MR indicated that AR is a significant causal risk factor for hazelnutFA (p
conclusionOur questionnaire enabled a large GWAS on self-reported FA in Dutch adults. We report one novel locus in the human leukocyte antigens (HLA) region associated with hazelnutFA, implying an association with antigen recognition. Our findings genetically link secondary FA to AR in adults.
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