ArticleJournal of the American Heart Association2024
Prognostic Value of Epicardial Adipose Tissue in Heart Failure With Mid-Range and Preserved Ejection Fraction: A Multicenter Study.
Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effect of SGLT2 inhibitors on cardiac structure and function assessed by cardiac magnetic resonance: a systematic review and meta-analysis.Cardiovascular diabetology · 2025Pooled it
- Prognostic value of epicardial adipose tissue in heart failure: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- The Heart's Hidden Influencer: Epicardial Adipose Tissue in the Pathogenesis of Heart Failure.Cardiology discovery · 2026Review
- Cardiovascular magnetic resonance-based arrhythmogenic substrate assessment improves sudden cardiac death risk stratification in heart failure with mildly reduced ejection fraction: a multicenter retrospective observational study.The Lancet regional health. Western Pacific · 2026Article
- Mediastinal adipose tissue as an active player in cardiovascular disease: a multimodality imaging narrative review.Quantitative imaging in medicine and surgery · 2026Review
- Cardiometabolic Heart Failure with Preserved Ejection Fraction (HFpEF): Epidemiology, Mechanisms, and the Role of Lifestyle Modification.Journal of cardiovascular development and disease · 2026Review
- Diabetes-related differences in body composition and their prognostic value among patients with heart failure and preserved ejection fraction: a cardiac-MRI-based study.Cardiovascular diabetology · 2026Article
- Epicardial adipose tissue as a determinant of heart failure prognosis: insights across ejection fraction phenotypes.Cardiovascular diabetology · 2026Review
- Epicardial fat remodeling in end-stage heart failure with reduced ejection fraction.Cardiovascular diabetology · 2026Article
- Do obesity and visceral adiposity promote heart failure with reduced ejection fraction?European heart journal · 2026Review
- Epicardial adipose tissue volume is associated with impaired left atrial mechanics in hypertensive overweight/obese patients: the potential mediating role of insulin resistance.Frontiers in nutrition · 2026Article
- Adipose tissue distribution in metabolic disease: depot-specific biology, clinical assessment, and therapeutic remodeling.Frontiers in endocrinology · 2026Review
- Epicardial adipose tissue volume stratifies atrial fibrillation subtypes in reduced ejection fraction heart failure: a CT-based predictor.Frontiers in cardiovascular medicine · 2026Article
- Epicardial adipose tissue in cardiovascular diseases: a potential therapeutic target.Frontiers in cardiovascular medicine · 2026Review
- Cardiac MRI in diabetic cardiomyopathy: translating imaging biomarkers into clinical practice.Cardiovascular diabetology · 2025Review
- Time to screen: rationale and roadmap for HFpEF screening in individuals with obesity.Heart failure reviews · 2025Review
- The Relationship Between Myocardial Fibrosis in Hypertensive Patients With Preserved Ejection Fraction and the Severity of Systemic Inflammatory Status Is Mediated by Epicardial Adipose Tissue: A Multicenter Cohort Study.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Beyond Traditional Risk Factors: Integrating Epicardial Adipose Tissue into the Comorbidity Landscape of HFpEF.Journal of clinical medicine · 2025Review
- Metabolic rewiring and inter-organ crosstalk in diabetic HFpEF.Cardiovascular diabetology · 2025Review
- Chronic Inflammation in Patients with Chronic Coronary Syndrome Who Have Been Taking Lipid-Lowering Drugs as a Residual Risk Factor - a Bidirectional Synergistic Correlation with Epicardial Adipose Tissue.Journal of inflammation research · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpicardial adipose tissue (EAT) accumulation is thought to play a role in the pathophysiology of heart failure (HF) with mid-range ejection fraction and HF with preserved ejection fraction, but its effect on outcome is unknown. METHODS AND
resultsA total of 692 patients with HF with mid-range ejection fraction or HF with preserved ejection fraction who underwent cardiovascular magnetic resonance at 2 medical centers in China between October 2016 and October 2022 were included in this study. EAT volume and extracellular volume were calculated using cardiovascular magnetic resonance. The main outcome was the composite of all-cause mortality and first HF hospitalization. Of 692 participants, 41.3% were women. The mean age, body mass index, left ventricular ejection fraction, and EAT volume were 57.0 years, 27.2 kg/m
conclusionsEAT accumulation is associated with an adverse prognosis in patients with HF with mid-range ejection fraction and those with HF with preserved ejection fraction. In addition, EAT provides incremental prognostic value beyond left ventricular ejection fraction and New York Heart Association class.
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