Evidence map›Paper›PMID 39673323›Full record

ArticleAmerican journal of epidemiology2025

Body size and occupational physical activity during the life course and gastrointestinal cancers.

Michele Sassano, Mahdi Nalini, Monireh Sadat Seyyedsalehi, Gholamreza Roshandel, Hossein Poustchi, Masoud Khoshnia, Farin Kamangar, Sanford M Dawsey, Christian Abnet, Reza Malekzadeh and 2 more

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In one paragraph

Article in American journal of epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Michele SassanoDepartment of Medical and Surgical Sciences, University of Bologna, Bologna 40138, Italy.ORCID 0000-0002-3158-1827
Mahdi NaliniMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States.
Monireh Sadat SeyyedsalehiDepartment of Medical and Surgical Sciences, University of Bologna, Bologna 40138, Italy.
Gholamreza RoshandelGolestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan 4917867439, Iran.
Hossein PoustchiLiver and Pancreaticobilliary Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran 1461884513, Iran.
Masoud KhoshniaGolestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan 4917867439, Iran.
Farin KamangarDepartment of Biology, School of Computer, Mathematical and Natural Sciences, Morgan State University, Baltimore, MD 21251, United States.
Sanford M DawseyMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States.
Christian AbnetMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States.
Reza MalekzadehDigestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran 1411713135, Iran.ORCID 0000-0002-9820-6335
Paolo BoffettaDepartment of Medical and Surgical Sciences, University of Bologna, Bologna 40138, Italy.
Arash EtemadiMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States.

Funding

Cancer Research UKInternational Agency for Research on CancerIntramural Research Program of the National Cancer Institute, National Institutes of HealthTehran University of Medical Sciences grant 81/15
6 · The paper itself

Abstract

Evidence is inconclusive regarding the associations of body size and occupational physical activity (PA) during the life course with gastrointestinal cancers. We analyzed data from the Golestan Cohort Study, a population-based, prospective cohort study from Iran, with 50 045 individuals aged 40-75 years enrolled during 2004-2008 and followed through April 2023. Body size during adolescence, early adulthood, and at cohort baseline was assessed using validated pictograms. Large adolescent body size was associated with total gastrointestinal cancers (hazard ratio [HR] = 1.09; 95% CI, 1.02-1.16) and liver cancer (HR = 1.49; 95% CI, 1.11-2.01). Large early-adulthood body size was associated with liver cancer (HR = 1.85; 95% CI, 1.35-2.52). Compared with normal weight during all stages, overweight or obesity during adolescence only or early adulthood only were associated with stomach cancer, esophageal squamous cell carcinoma, and liver cancer. Lower levels of adolescent occupational PA were associated with colon cancer (HR = 1.39; 95% CI, 1.10-1.75), whereas lower levels at cohort baseline were positively associated with colon cancer and inversely associated with rectal cancer. Our findings suggest that timing of obesity during the life course might differently affect risk of gastrointestinal cancers, whereas occupational PA was associated with colon cancer only.

Indexed as

Body SizeExerciseGastrointestinal NeoplasmsAdolescentAdultAgedFemaleHumansIranLiver NeoplasmsMaleMiddle AgedObesityProspective StudiesRisk Factorscohortgastrointestinal cancerIranobesityphysical activity

Identifiers

PMID39673323
PMCPMC12671977

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