Evidence map›Paper›PMID 39673117›Full record

ArticleNanotoxicology2024

CoCrMo nanoparticle induces neurotoxicity mediated via mitochondrial dysfunction: a study model for implant derived nanoparticle effects.

Priyadarshini Vijayakumar, Yongchao Mou, Xuejun Li, Jahnavi Anil, Neeraja Revi, Kai-Yuan Cheng, Mathew T Mathew, Divya Bijukumar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanotoxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Priyadarshini VijayakumarDepartment of Biomedical Sciences, University of Illinois College of Medicine Rockford, Rockford, IL, USA.
Yongchao MouDepartment of Biomedical Sciences, University of Illinois College of Medicine Rockford, Rockford, IL, USA.
Xuejun LiDepartment of Biomedical Sciences, University of Illinois College of Medicine Rockford, Rockford, IL, USA.
Jahnavi AnilDepartment of Biomedical Sciences, University of Illinois College of Medicine Rockford, Rockford, IL, USA.
Neeraja ReviDepartment of Biomedical Sciences, University of Illinois College of Medicine Rockford, Rockford, IL, USA.
Kai-Yuan ChengDepartment of Biomedical Sciences, University of Illinois College of Medicine Rockford, Rockford, IL, USA.
Mathew T MathewDepartment of Biomedical Sciences, University of Illinois College of Medicine Rockford, Rockford, IL, USA.
Divya BijukumarDepartment of Biomedical Sciences, University of Illinois College of Medicine Rockford, Rockford, IL, USA.

Funding

The role of CoCr nano metal degradation products (DPs) on alteration of DNA replication and repair mechanism in neural cell environment: Toxicology aspectsR03NS111554 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BIJUKUMAR, DIVYA RANI, MATHEW, MATHEW THOPPIL · 2019 to 2020
$160k
NINDS NIH HHS R03 NS111554
6 · The paper itself

Abstract

Toxicity associated with elevated levels of cobalt-chromium-molybdenum (CoCrMo) nanoparticles in total hip replacement (THR) patients has been a rising concern. Recent investigations demonstrated that these particles can induce polyneuropathy in THR patients. The current study aims to address a detailed molecular investigation of CoCrMo nanoparticle-mediated mitochondrial dynamics using induced pluripotent stem cell-derived neurons (iPSC neurons). Telencephalic neurons from iPSCs were used in this study. A statistically significant dose-dependent reduction in membrane potential and mitochondrial superoxide generation was observed after CoCrMo nanoparticle treatment. The gene expression analysis confirmed that the oxidative-specific genes were significantly upregulated in particle-treated cells compared to untreated cells. When iPSCs were exposed to CoCrMo nanoparticles, there was a significant reduction in the area, perimeter, and length of mitochondria. Live cell imaging (mitochondrial tracking) revealed a significant reduction in mitochondrial movements in the presence of CoCrMo nanoparticles. Further protein expression confirmed increased mitochondrial fission in CoCrMo particle-treated cells by significantly upregulating Drp-1 protein and downregulating Mfn-2. In conclusion, the results show that CoCrMo nanoparticles can significantly alter neuronal mitochondrial dynamics. The disturbance in balance restricts mitochondrial movement, reduces energy production, increases oxidative stress, and can cause subsequent neurodegeneration.

Indexed as

Induced Pluripotent Stem CellsMitochondriaNeuronsCells, CulturedCobaltHumansMembrane Potential, MitochondrialMetal NanoparticlesMitochondrial DynamicsNanoparticlesOxidative StressVitalliumCobaltVitalliumCoCrMoiPSC neuronsmitochondrial dynamicsnanoparticlesTHR

Identifiers

PMID39673117
PMCPMC11789272

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.