ArticleThe American journal of case reports2024
Efficacy of Cold Atmospheric Plasma in Chronic Diabetic Foot Ulcer Management: A Case Report.
Article in The American journal of case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A dual-index framework for cold atmospheric plasma dosing: A meta-analysis of parametric control from volumetric redox flux to redox homeostatic status.Redox biology · 2026Pooled it
- An injectable hyaluronic acid-silanol hydrogel containing arginine and puerarin for immune modulation and enhanced diabetic wound healing.Bioactive materials · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Diabetes mellitus is a significant global health issue, affecting millions and costing billions annually in management. A major complication of diabetes is foot ulcers, which heal slowly due to nerve damage (neuropathy) and poor circulation. These ulcers have a high risk of infection and, if untreated, can lead to amputation. The rise of antibiotic-resistant bacteria further complicates treatment, making traditional methods like wound cleaning, dressings, and antibiotics less effective. Cold atmospheric plasma (CAP) therapy is a noninvasive, innovative treatment showing promise in addressing these wounds. CAP generates reactive oxygen and nitrogen species that stimulate cell growth, migration, and proliferation, which are critical for wound healing. It also kills bacteria, including antibiotic-resistant strains, preventing infection and promoting tissue regeneration. Additionally, CAP encourages release of growth factors and cytokines, helping tissue repair and reducing inflammation. Unlike traditional treatments, CAP targets harmful bacteria without harming healthy tissue, making it safer and more effective for treating non-healing wounds. This case highlights a 69-year-old man with a chronic diabetic foot ulcer, previously unresponsive to standard treatments, who experienced successful healing with CAP therapy. CASE REPORT A 69-year-old man with a chronic non-healing diabetic foot ulcer on the plantar surface of his left foot underwent multiple failed treatments over 60 weeks, including traditional wound care and advanced clinical trials, before being treated with CAP, leading to significant wound closure over the course of 15 weeks. CONCLUSIONS This report has highlighted the challenges of managing chronic diabetic foot ulcers and has shown that CAP can promote wound healing.
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