Evidence map›Paper›PMID 39673020›Full record

ArticleEuropean archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry2025

Prevalence of hypomineralised second primary molars and molar incisor hypomineralisation in patients with cleft lip and/or palate.

L S van der Knaap-Kind, N van der Kaaij, S Nijst, E Verhulst, M Koudstaal, E Wolvius, L Kragt

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Article in European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Prevalence and characteristics of hypomineralised second primary molars in Irish school children.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026
    Article
  2. Differential diagnosis of molar incisor hypomineralisation and hypomineralised second primary molars: a scoping review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026
    Review
  3. Cleft lip and palate are associated with a higher prevalence of molar-incisor hypomineralisation: a cross-sectional study with a comparison group.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

L S van der Knaap-KindDepartment of Oral and Maxillofacial Surgery, Special Dental Care and Orthodontics, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands. l.kind@erasmusmc.nl.ORCID http://orcid.org/0000-0003-3851-9257
N van der KaaijDepartment of orthodontics, Academic Center for Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-1776-5061
S NijstDepartment of Oral and Maxillofacial Surgery, Special Dental Care and Orthodontics, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.
E VerhulstDepartment of Oral and Maxillofacial Surgery, Special Dental Care and Orthodontics, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.
M KoudstaalDepartment of Oral and Maxillofacial Surgery, Special Dental Care and Orthodontics, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-5060-7711
E WolviusDepartment of Oral and Maxillofacial Surgery, Special Dental Care and Orthodontics, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-5159-3497
L KragtDepartment of Oral and Maxillofacial Surgery, Special Dental Care and Orthodontics, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-4223-429X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to determine the prevalence of hypomineralised second primary molars (HSPM) and molar incisor hypomineralisation (MIH) in cleft lip and/or palate (CL/P) patients.

methodsA retrospective analysis of intraoral photographs of CL/P patients was done. All patients born between 2000 and 2011, and visiting the cleft team of the Erasmus Medical Center in Rotterdam, The Netherlands, were included. Their photos were scored on the presence and severity of HSPM and MIH using criteria formulated by the European Academy of Pediatric Dentistry. The outcomes were compared with data of the general population, extracted from the Generation R study.

resultsThe photos of 535 CL/P patients were evaluated. The overall prevalence of HSPM in CL/P patients was 15.2%, of MIH 12.8%. HSPM and MIH prevalence was significantly higher (both p < 0.001) compared to prevalence in the general population. No significant differences were found in prevalence of HSPM nor of MIH in CL/P patients based on gender (p = 0.891 resp. p = 0.405), cleft type (p = 0.282, resp. p = 0.415), Pierre Robin (p = 0.837, resp. p = 0.169) or other comorbidities (p = 0.553, resp. p = 0.617). CL/P patients with HSPM were almost 3 times more likely diagnosed with MIH than CL/P patients without HSPM (OR = 2.57, p = 0.002).

conclusionThe prevalence of HSPM and MIH is higher in patients with CL/P than in the general population.

Indexed as

Cleft LipCleft PalateDental Enamel HypoplasiaIncisorMolarTooth, DeciduousChildChild, PreschoolFemaleHumansMaleNetherlandsPrevalenceRetrospective StudiesCleftHypomineralised second primary molarsMolar incisor hypomineralisationPrevalence

Identifiers

PMID39673020

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.