Evidence map›Paper›PMID 39672938›Full record

ArticlePediatric cardiology2026

Echocardiographic Changes in Infants with Severe Congenital Diaphragmatic Hernia After Fetoscopic Endoluminal Tracheal Occlusion (FETO).

Catherine M Avitabile, Sabrina Flohr, Leny Mathew, Yan Wang, Devon Ash, Juliana S Gebb, Natalie E Rintoul, Holly L Hedrick

Abstract read
In one paragraph

Article in Pediatric cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Catherine M AvitabileDepartment of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. avitabilec@chop.edu.ORCID http://orcid.org/0000-0002-2354-5447
Sabrina FlohrDivision of Pediatric General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Leny MathewDivision of Pediatric General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Yan WangDivision of Cardiology, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, 8NW49, Philadelphia, PA, 19104, USA.
Devon AshDivision of Cardiology, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, 8NW49, Philadelphia, PA, 19104, USA.
Juliana S GebbRichard D. Wood Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Natalie E RintoulDepartment of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Holly L HedrickDivision of Pediatric General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Funding

Understanding the Barriers to Physical Activity in Pediatric Pulmonary Hypertension in Order to Design Effective Home-based Exercise ProgramsK23HL150337 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI AVITABILE, CATHERINE M. · 2021 to 2025
$818k
Doris Duke Charitable Foundation 2021262NHLBI NIH HHS K23 HL150337
6 · The paper itself

Abstract

Fetoscopic endoluminal tracheal occlusion (FETO) induces lung growth and may improve survival in congenital diaphragmatic hernia (CDH) but the effect on post-natal right (RV) and left (LV) ventricular size and cardiac function is unknown. Quantitative measures of heart size and function including tricuspid annular plane systolic excursion Z-score (TAPSEZ), RV fractional area change (RVFAC), RV global longitudinal and free wall strain (RVGLS, RVFWS), RV/LV ratio, LV eccentricity index (LVEI), and LV M-mode diastolic and systolic Z-scores (LVIDDZ, LVIDSZ) were compared between FETO and control patients on first post-natal echocardiogram, prior to and post CDH repair, and on last available echocardiogram using non-parametric Wilcoxon rank-sum test in a single-center, retrospective cohort study. Linear regression models evaluated change over time, adjusting for clustering and interaction of echocardiogram parameters with time. Thirty-two patients (10 FETO, 22 control) met inclusion criteria. At first echocardiogram, FETO patients demonstrated lower RV/LV ratio and LVEI (p = 0.01 for both) indicating less RV dilation and less ventricular septal displacement, respectively. LV hypoplasia was less severe in FETO patients (p = 0.01 for both LVIDDZ and LVIDSZ) initially. After repair, FETO patients demonstrated better RV systolic function compared to control patients by FAC (p < 0.01), RVGLS (p = 0.02), and RVFWS (p = 0.05). Over time, FETO patients demonstrated greater improvements in RV/LV ratio and LVEI but smaller increases in LV dimensions compared to control patients. Improvements in RV function were similar between the groups. FETO patients demonstrate differences in cardiac size and function compared to control patients.

Indexed as

EchocardiographyFetoscopyHeart VentriclesHernias, Diaphragmatic, CongenitalTracheaFemaleHumansInfantInfant, NewbornMalePregnancyRetrospective StudiesTreatment OutcomeCongenital diaphragmatic herniaEchocardiogramPulmonary hypertensionStrain

Identifiers

PMID39672938
PMCPMC12163094

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.