Evidence map›Paper›PMID 39672902›Full record

ArticleThe Journal of antibiotics2025

Structure-function analysis of 2-sulfamoylacetic acid synthase in altemicidin biosynthesis.

Takahiro Mori, Kosuke Sakurada, Takayoshi Awakawa, Haibin He, Richiro Ushimaru, Ikuro Abe

Abstract read
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Article in The Journal of antibiotics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Takahiro Mori *Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan. tmori@mol.f.u-tokyo.ac.jp.ORCID 0000-0002-2754-5858
Kosuke Sakurada *Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Takayoshi AwakawaGraduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan. takayoshi.awakawa@riken.jp.
Haibin HeGraduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Richiro UshimaruGraduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-4071-3326
Ikuro AbeGraduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan. abei@mol.f.u-tokyo.ac.jp.ORCID 0000-0002-3640-888X

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) 22H05123MEXT | Japan Society for the Promotion of Science (JSPS) 23H02641MEXT | Japan Society for the Promotion of Science (JSPS) JP23H00393
6 · The paper itself

Abstract

Altemicidin and its analogs are valuable sulfonamide antibiotics with valuable antitumor and antibacterial activities. Structures of altemicidin and congeners feature an unusual sulfonamide side chain. In the biosynthesis of altemicidin, the aldehyde dehydrogenase SbzJ catalyzes the conversion of 2-sulfamoylacetic aldehyde into 2-sulfamoylacetic acid, a key step in producing the sulfonamide side chain. Here, we conducted the biochemical characterization and structure-function analysis of SbzJ. In vitro assays revealed that SbzJ exhibits substrate promiscuity, accepting various aldehyde substrates and cofactors. The crystal structure of SbzJ in complex with NAD

Indexed as

SulfonamidesAldehyde DehydrogenaseAnti-Bacterial AgentsCrystallography, X-RayNADStreptomycesStructure-Activity RelationshipSubstrate SpecificityAldehyde DehydrogenaseAnti-Bacterial AgentsNADSulfonamides

Identifiers

PMID39672902

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.