ArticleAlcohol, clinical & experimental research2025
Connectivity of the neuronal network for contextual fear memory is disrupted in a mouse model of third-trimester binge-like ethanol exposure.
Article in Alcohol, clinical & experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Third trimester-equivalent alcohol exposure reduces neurons in males and increases Vglut2Neuropharmacology · 2026Article
- Large-scale in vivo electrophysiology analysis reveals opposing thalamic and hippocampal excitability after third-trimester-equivalent alcohol exposure in mice.Journal of neurophysiology · 2026Article
- Unsupervised Phenotyping Reveals Disrupted Neural Firing Characteristics in the Anterior Thalamus and Surrounding Brain Regions Following Third-Trimester Equivalent Alcohol Exposure in Mice.bioRxiv : the preprint server for biology · 2025Article
- Impact of acute binge-like ethanol exposure during the third-trimester equivalent on subicular interneurons in mice.The American journal of drug and alcohol abuse · 2025Article
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Authors and funding
20 authors.
Funding
Abstract
backgroundIn rodents, third-trimester-equivalent alcohol exposure (TTAE) produces significant deficits in hippocampal-dependent memory processes such as contextual fear conditioning (CFC). The present study sought to characterize changes in both behavior and Fos
methodsOn postnatal day 7, mice received either two injections of saline or 2.5 g/kg EtOH spaced 2 h apart. The mice were left undisturbed until they reached adulthood, at which point they underwent CFC. After context exposure on day 2, mice received a tamoxifen injection. Brain tissue was harvested. Slides were automatically imaged using a Zeiss AxioScanner. Manual counts on a priori regions of interest were conducted. Automated counts were performed on the whole brain using the QUINT 2D stitching pipeline. Last, novel network analyses were applied to identify future regions of interest.
resultsTTAE reduced context recall on day 2 of CFC. Fos DISCUSSION: These results suggest that CFC is mediated by the limbic memory system and is disrupted following TTAE. Given the increase in CA1 and CA3 activity, a potential hypothesis is that TTAE causes disruptions to memory encoding following day 1 conditioning. Future studies will aim to determine whether this disruption specifically affects the encoding or retrieval of fear memories.
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