Evidence map›Paper›PMID 39672547›Full record

ReviewAmerican journal of physiology. Cell physiology2025

Prevention of cardiovascular disease in women with type 2 diabetes: the role of incretin mimetics and sodium-glucose cotransporter-2 inhibitors.

Eiman Ibrahim, Mya Burken, Guido Lastra, Camila Manrique-Acevedo

Abstract readReview
In one paragraph

Review in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Living with PCOS: A Narrative of its Biology, Diagnosis, and Evolving Treatment.Endocrine, metabolic & immune disorders drug targets · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Eiman IbrahimDivision of Endocrinology and Metabolism, Department of Medicine, University of Missouri, Columbia, Missouri, United States.
Mya BurkenDivision of Endocrinology and Metabolism, Department of Medicine, University of Missouri, Columbia, Missouri, United States.
Guido LastraDivision of Endocrinology and Metabolism, Department of Medicine, University of Missouri, Columbia, Missouri, United States.ORCID 0000-0001-9205-1021
Camila Manrique-AcevedoDivision of Endocrinology and Metabolism, Department of Medicine, University of Missouri, Columbia, Missouri, United States.ORCID 0000-0001-9341-404X

Funding

Estrogen receptor alpha signaling in endothelial cells exacerbates arterial stiffening via upregulation of ENaC in insulin resistant femalesR01HL142770 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI MANRIQUE ACEVEDO, CAMILA MARGARITA · 2019 to 2023
$3.7M
SGLT2 inhibition as a therapeutic strategy to reverse arterial stiffening in agingR01AG082413 · NIA · UNIVERSITY OF MISSOURI-COLUMBIA · PI Camila Margarita Manrique Acevedo, Luis A Martinez-Lemus · 2024 to 2026
$1.8M
Sex-related differences in arterial stiffness in type 2 diabetics: role of uric acidR21DK116081 · NIDDK · UNIVERSITY OF MISSOURI-COLUMBIA · PI MANRIQUE ACEVEDO, CAMILA MARGARITA · 2018 to 2020
$581k
CSRD VA I01 CX002399HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL142770HHS | NIH | National Institute on Aging (NIA) R01AG082413NHLBI NIH HHS R01 HL142770NIA NIH HHS R01 AG082413NIDDK NIH HHS R21 DK116081U.S. Department of Veterans Affairs (VA) 1I01CX002399
6 · The paper itself

Abstract

Cardiovascular disease (CVD) is the leading cause of death among individuals with type 2 diabetes (T2D), with women experiencing a disproportionate risk of events compared with men. Women have an amplified burden of cardiovascular risk factors once T2D is diagnosed. Incretin mimetics now plays a central role in managing cardiovascular risk by improving glycemic control, promoting weight loss, and potentially exerting direct cardioprotective effects. Similarly, sodium-glucose cotransporter-2 inhibitors contribute to CVD prevention through various nonglucose-lowering mechanisms. Both classes of medications are integral to personalized treatment strategies aimed at addressing the heightened cardiovascular risk faced by women with diabetes. This mini-review addresses possible mechanisms underlying the increased cardiovascular risk and explores the role of incretin mimetics and SGLT2 inhibitors in mitigating CVD in women with T2D. Emphasizing personalized and sex-specific approaches in diabetes care is crucial for optimizing treatment outcomes and improving cardiovascular health.

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, Type 2IncretinsSodium-Glucose Transporter 2 InhibitorsAnimalsFemaleGlucagon-Like Peptide-1 Receptor AgonistsHeart Disease Risk FactorsHumansHypoglycemic AgentsGlucagon-Like Peptide-1 Receptor AgonistsHypoglycemic AgentsIncretinsSodium-Glucose Transporter 2 Inhibitorscardiovascular diseasediabetesincretin mimeticssex differencesSGLT2 inhibitors

Identifiers

PMID39672547
PMCPMC11901335

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.