Evidence map›Paper›PMID 39672164›Full record

ArticleCancer cell2025

Stressing the importance of circadian time in treatment responses.

Katja A Lamia

Abstract read
In one paragraph

Article in Cancer cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Katja A LamiaDepartment of Molecular and Cellular Biology and Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA, USA. Electronic address: klamia@scripps.edu.

Funding

Impacting Cell Growth through altered circadian proteolysisR01CA211187 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI Katja A Lamia · 2017 to 2026
$4.6M
Establishing a mechanistic basis for enhanced tumorigenesis under chronic circadian disruptionR01CA271500 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI Katja A Lamia · 2023 to 2026
$2.4M
NCI NIH HHS R01 CA211187NCI NIH HHS R01 CA271500
6 · The paper itself

Abstract

Circadian disruption increases cancer risk, but connections between circadian clocks and cancer biology are diverse and depend on tumor type. In this issue of Cancer Cell, Gonzalez-Aponte et al. demonstrate that circadian timing of glucocorticoid exposure affects glioblastoma growth. These findings underscore the importance of timing in designing therapeutic interventions.

Indexed as

Brain NeoplasmsCircadian ClocksCircadian RhythmGlioblastomaGlucocorticoidsAnimalsHumansGlucocorticoids

Identifiers

PMID39672164
PMCPMC13016167

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.