Evidence map›Paper›PMID 39672154›Full record

ArticleStem cell reports2025

Elevated hematopoietic stem cell frequency in mouse alveolar bone marrow.

Kouta Niizuma, Satoru Morikawa, Eric Gars, Jinyi Xiang, Tomoko Matsubara-Takahashi, Rei Saito, Eri Takematsu, Yuting Wang, Haojun Xu, Arata Wakimoto and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Kouta NiizumaInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Satoru MorikawaInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Dentistry and Oral Surgery, Keio University School of Medicine, Tokyo, Japan.
Eric GarsInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jinyi XiangInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Tomoko Matsubara-TakahashiDepartment of Anatomy, Keio University School of Medicine, Tokyo, Japan.
Rei SaitoDepartment of Anatomy, Keio University School of Medicine, Tokyo, Japan.
Eri TakematsuInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, US.
Yuting WangInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, US.
Haojun XuDepartment of Neurology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Arata WakimotoPh.D. Program in Human Biology, School of Integrative and Global Majors, University of Tsukuba, Ibaraki 305-8575, Japan.
Tze Kai TanInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Yoshiaki KubotaDepartment of Anatomy, Keio University School of Medicine, Tokyo, Japan.
Charles K F ChanInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, US.
Irving L WeissmanInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Taneaki NakagawaDepartment of Dentistry and Oral Surgery, Keio University School of Medicine, Tokyo, Japan.
Adam C WilkinsonInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Hiromitsu NakauchiInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Division of Stem Cell Therapy, Distinguished Professor Unit, Institute of Medical Science, The University of Tokyo, Tokyo, Japan. Electronic address: nakauchi@stanford.edu.
Ryo YamamotoInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto 606-8501, Japan. Electronic address: yamamoto.ryo.2c@kyoto-u.ac.jp.

Funding

Modulating HSC-niche interactions to understand aging and improve transplantationR01HL147124 · NHLBI · STANFORD UNIVERSITY · PI NAKAUCHI, HIROMITSU · 2018 to 2021
$1.6M
Valine as a Metabolic Modulator of HematopoiesisR01DK116944 · NIDDK · STANFORD UNIVERSITY · PI NAKAUCHI, HIROMITSU · 2018 to 2021
$1.5M
Regulating Skeletal Stem Cell and Neutrophil Dynamics for Improved Cleft Palate Bone Regeneration by Newly Designed Surrogate Bone Morphogenetic Protein-2K99DE032773 · NIDCR · STANFORD UNIVERSITY · PI Eri Takematsu · 2025 to 2026
$259k
NHLBI NIH HHS R01 HL147124NIDCR NIH HHS K99 DE032773NIDDK NIH HHS R01 DK116944
6 · The paper itself

Abstract

Hematopoietic stem cells (HSCs) are crucial for maintaining hematopoietic homeostasis and are localized within distinct bone marrow (BM) niches. While BM niches are often considered similar across different skeletal sites, we discovered that the alveolar BM (al-BM) in the mandible harbors the highest frequency of immunophenotypic HSCs in nine different skeletal sites. Transplantation assays revealed significantly increased engraftment from al-BM compared to femur, tibia, or pelvis BM, likely due to a higher proportion of alveolar HSCs. Moreover, hematopoietic progenitor cells (c-Kit

Indexed as

Bone MarrowBone Marrow CellsHematopoietic Stem CellsAnimalsApoptosisHematopoiesisHematopoietic Stem Cell TransplantationMesenchymal Stem CellsMiceMice, Inbred C57BLStem Cell Nicheal-BMalveolar bone marrowbone marrow microenvironmenthematopoietic stem cellsHSCsmandiblemesenchymal stromal cellsMSCsnicheoncostatin Mquiescenceskeletal stem cellsstem cell frequency

Identifiers

PMID39672154
PMCPMC11784484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.