ArticleCell2024
How to build the virtual cell with artificial intelligence: Priorities and opportunities.
Abstract read
In one paragraph
Article in Cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 186 papers.
0numbers the graph read from it
0cells of the map it votes in
186citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
186 citing papers in PubMed.
- Computational approaches for multimodal lineage tracing.Nature reviews. Genetics · 2026Review
- From blueprint to build: Metal ions in peripheral nerve development and engineering regeneration.Bioactive materials · 2026Review
- Single-Nucleus Multi-Omic Atlas Maps Regulatory Architecture and Non-Coding Variant Effects across Adult Human Tissues.bioRxiv : the preprint server for biology · 2026Article
- Review
- A systematic comparison of single-cell perturbation response prediction models.Science advances · 2026Article
- Learning stochastic dynamics and cell-fate landscapes from single-cell snapshots via optimal transport.Science advances · 2026Article
- Article
- GenoME: a MoE-based generative model for individualized, multimodal prediction and perturbation of genomic profiles.Nucleic acids research · 2026Article
- Artificial intelligence virtual bone organoids (AIVBOs).Journal of orthopaedic translation · 2026Review
- Article
- Benchmarking biomedical foundation models.Nature methods · 2026Review
- How to build an AI-driven digital organism.Nature medicine · 2026Review
- AI proteomics: from protein identification to virtual cells.Nature methods · 2026Review
- Towards predictive virtual embryos with genomics and AI.Nature methods · 2026Article
- Post-genome-wide association study variant-to-function challenges in asthma research.The Journal of allergy and clinical immunology · 2026Review
- Article
- Bringing human early embryo development to clinical interpretation: HESTA as an evolving reference.Clinical and translational medicine · 2026Article
- scProtoTransformer: Scalable reference mapping across molecules, cells, and donors.Science advances · 2026Article
- Data-centric feedback loops for next-generation immunotherapy development.Nature biomedical engineering · 2026Review
- Article
126 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Update of
Authors and funding
42 authors.
Charlotte BunneDepartment of Computer Science, Stanford University, Stanford, CA, USA; Genentech, South San Francisco, CA, USA; Chan Zuckerberg Initiative, Redwood City, CA, USA; School of Computer and Communication Sciences and School of Life Sciences, EPFL, Lausanne, Switzerland.
Yusuf RoohaniDepartment of Computer Science, Stanford University, Stanford, CA, USA; Chan Zuckerberg Initiative, Redwood City, CA, USA; Arc Institute, Palo Alto, CA, USA.
Yanay RosenDepartment of Computer Science, Stanford University, Stanford, CA, USA; Chan Zuckerberg Initiative, Redwood City, CA, USA.
Ankit GuptaChan Zuckerberg Initiative, Redwood City, CA, USA; Department of Protein Science, Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden.
Xikun ZhangDepartment of Computer Science, Stanford University, Stanford, CA, USA; Chan Zuckerberg Initiative, Redwood City, CA, USA; Department of Bioengineering, Stanford University, Stanford, CA, USA.
Marcel RoedDepartment of Computer Science, Stanford University, Stanford, CA, USA; Chan Zuckerberg Initiative, Redwood City, CA, USA.
Theo AlexandrovDepartment of Pharmacology, University of California, San Diego, San Diego, CA, USA; Department of Bioengineering, University of California, San Diego, San Diego, CA, USA.
Mohammed AlQuraishiDepartment of Bioengineering, University of California, San Diego, San Diego, CA, USA.
Patricia BrennanChan Zuckerberg Initiative, Redwood City, CA, USA.
Daniel B BurkhardtCellarity, Somerville, MA, USA.
Andrea CalifanoDepartment of Systems Biology, Columbia University, New York, NY, USA; Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA; Chan Zuckerberg Biohub, New York, NY, USA.
Jonah CoolChan Zuckerberg Initiative, Redwood City, CA, USA.
Abby F DernburgDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Kirsty EwingChan Zuckerberg Initiative, Redwood City, CA, USA.
Emily B FoxDepartment of Computer Science, Stanford University, Stanford, CA, USA; Department of Statistics, Stanford University, Stanford, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA.
Matthias HauryChan Zuckerberg Institute for Advanced Biological Imaging, Redwood City, CA, USA.
Amy E HerrChan Zuckerberg Biohub, San Francisco, CA, USA; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.
Eric HorvitzMicrosoft Research, Redmond, WA, USA.
Patrick D HsuArc Institute, Palo Alto, CA, USA; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA; Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA.
Viren JainGoogle Research, Mountain View, CA, USA.
Gregory R JohnsonNewLimit, San Francisco, CA, USA.
Thomas KalilSchmidt Futures, New York, NY, USA.
David R KelleyCalico Life Sciences LLC, San Francisco, CA, USA.
Shana O KelleyChan Zuckerberg Biohub, Chicago, IL, USA; Northwestern University, Evanston, IL, USA.
Anna KreshukCell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Tim MitchisonDepartment of Systems Biology, Harvard Medical School, Boston, MA, USA.
Stephani OtteChan Zuckerberg Institute for Advanced Biological Imaging, Redwood City, CA, USA.
Jay ShendureDepartment of Genome Sciences, University of Washington, Seattle, WA, USA; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA; Seattle Hub for Synthetic Biology, Seattle, WA, USA; Howard Hughes Medical Institute, Seattle, WA, USA.
Nicholas J SofroniewEvolutionaryScale, PBC, New York, NY, USA.
Fabian TheisInstitute of Computational Biology, Helmholtz Center Munich, Munich, Germany; School of Computing, Information and Technology, Technical University of Munich, Munich, Germany; TUM School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany.
Christina V TheodorisGladstone Institute of Cardiovascular Disease, Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
Srigokul UpadhyayulaDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Marc ValerChan Zuckerberg Initiative, Redwood City, CA, USA.
Bo WangDepartment of Computer Science, University of Toronto, Toronto, ON, Canada; Vector Institute, Toronto, ON, Canada.
Eric XingCarnegie Mellon University, School of Computer Science, Pittsburgh, PA, USA; Mohamed Bin Zayed University of Artificial Intelligence, Abu Dhabi, United Arab Emirates.
Serena Yeung-LevyDepartment of Computer Science, Stanford University, Stanford, CA, USA; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA.
Marinka ZitnikDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA; Kempner Institute for the Study of Natural and Artificial Intelligence, Harvard University, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Theofanis KaraletsosChan Zuckerberg Initiative, Redwood City, CA, USA. Electronic address: tkaraletsos@chanzuckerberg.com.
Aviv RegevGenentech, South San Francisco, CA, USA. Electronic address: regev.aviv@gene.com.
Emma LundbergChan Zuckerberg Initiative, Redwood City, CA, USA; Department of Protein Science, Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden; Department of Bioengineering, Stanford University, Stanford, CA, USA; Department of Pathology, Stanford University, Stanford, CA, USA. Electronic address: emmalu@stanford.edu.
Jure LeskovecDepartment of Computer Science, Stanford University, Stanford, CA, USA; Chan Zuckerberg Initiative, Redwood City, CA, USA. Electronic address: jure@cs.stanford.edu.
Stephen R QuakeChan Zuckerberg Initiative, Redwood City, CA, USA; Department of Bioengineering, Stanford University, Stanford, CA, USA; Department of Applied Physics, Stanford University, Stanford, CA, USA. Electronic address: steve@czbiohub.org.
Funding
Bridge2AI: Cell Maps for AI (CM4AI) Data Generation ProjectOT2OD032742 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jean-Christophe Bélisle-Pipon, TIMOTHY W CLARK · 2022 to 2026
$21.5MThe Cancer Cell Map Initiative v2.0U54CA274502 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Trey Ideker · 2022 to 2026
$14.2MNCI NIH HHS U54 CA274502NIH HHS OT2 OD032742
Abstract
Cells are essential to understanding health and disease, yet traditional models fall short of modeling and simulating their function and behavior. Advances in AI and omics offer groundbreaking opportunities to create an AI virtual cell (AIVC), a multi-scale, multi-modal large-neural-network-based model that can represent and simulate the behavior of molecules, cells, and tissues across diverse states. This Perspective provides a vision on their design and how collaborative efforts to build AIVCs will transform biological research by allowing high-fidelity simulations, accelerating discoveries, and guiding experimental studies, offering new opportunities for understanding cellular functions and fostering interdisciplinary collaborations in open science.
Indexed as
Artificial IntelligenceAnimalsComputer SimulationHumansModels, BiologicalNeural Networks, ComputerAIcell biologyMLvirtual cell
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.