ArticleScience advances2024
Transcription processes compete with loop extrusion to homogenize promoter and enhancer dynamics.
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Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
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Who cites it
26 citing papers in PubMed.
- Senescent cells cluster CTCF on nuclear speckles to instruct an alternative splicing program.Nature aging · 2026Article
- Enhancer control of promoter activity and variability via frequency modulation of clustered transcriptional bursts.Nature genetics · 2026Article
- Genome-wide absolute quantification of chromatin looping.Nature structural & molecular biology · 2026Article
- Live-cell imaging of enhancer-promoter dynamics reveals transient contact-driven gene activation.bioRxiv : the preprint server for biology · 2026Article
- Integrated MINFLUX tracking reveals two distinct chromatin dynamics classes across cell types.Nature structural & molecular biology · 2026Article
- Cohesin-mediated loop extrusion and enhancer-associated factors additively contribute toGenes & development · 2026Article
- Loop extrusion by cohesin plays a role in enhancer-activated gene expression early in differentiation.Nature communications · 2026Article
- Review
- TAD boundaries and gene activity are uncoupled.eLife · 2026Article
- Chromatin dynamics of the Klf4 locus in mouse pluripotent cells.Scientific reports · 2026Article
- TAD boundaries and gene activity are uncoupled.bioRxiv : the preprint server for biology · 2026Article
- Synergy between regulatory elements can render cohesin dispensable for distal enhancer function.Science (New York, N.Y.) · 2026Article
- Visualizing genetic information flow in space and time.Science China. Life sciences · 2025Review
- Nanoscale dynamics of enhancer-promoter interactions during exit from pluripotency.Nucleic acids research · 2025Article
- RETRACTED: Kinetic organization of the genome revealed by ultraresolution multiscale live imaging.Science (New York, N.Y.) · 2025Article
- Timing is everything: transcription bursting in development.Genes & development · 2025Review
- CTCF depletion decouples enhancer-mediated gene activation from chromatin hub formation.Nature structural & molecular biology · 2025Article
- Bridging spatial and temporal scales of developmental gene regulation.Current opinion in genetics & development · 2025Review
- A Sox2 enhancer cluster regulates region-specific neural fates from mouse embryonic stem cells.G3 (Bethesda, Md.) · 2025Article
- Liquid condensates: a new barrier to loop extrusion?Cellular and molecular life sciences : CMLS · 2025Review
Corrections and comments
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Authors and funding
20 authors.
Angeliki PlataniaDepartment of Functional Genomics and Cancer, Institute of Genetics and Molecular and Cellular Biology (IGBMC), UMR7104, Centre National de la Recherche Scientifique, U1258, Institut National de la Santé et de la Recherche Médicale, University of Strasbourg, 6704 Illkirch, France.ORCID 0009-0002-4721-8771
Cathie ErbDepartment of Functional Genomics and Cancer, Institute of Genetics and Molecular and Cellular Biology (IGBMC), UMR7104, Centre National de la Recherche Scientifique, U1258, Institut National de la Santé et de la Recherche Médicale, University of Strasbourg, 6704 Illkirch, France.ORCID 0000-0001-8972-9831
Mariano BarbieriTranslational Epigenetics Group, Institute of Pathology, University Medical Centre Göttingen, Göttingen, Germany.ORCID 0000-0002-9080-631X
Bastien MolcretteDepartment of Functional Genomics and Cancer, Institute of Genetics and Molecular and Cellular Biology (IGBMC), UMR7104, Centre National de la Recherche Scientifique, U1258, Institut National de la Santé et de la Recherche Médicale, University of Strasbourg, 6704 Illkirch, France.ORCID 0000-0002-5995-5376
Erwan GrandgirardDepartment of Functional Genomics and Cancer, Institute of Genetics and Molecular and Cellular Biology (IGBMC), UMR7104, Centre National de la Recherche Scientifique, U1258, Institut National de la Santé et de la Recherche Médicale, University of Strasbourg, 6704 Illkirch, France.ORCID 0000-0002-5263-2144
Marit A C de KortDivision of Gene Regulation, the Netherlands Cancer Institute, Oncode Institute, 1066CX Amsterdam, Netherlands.
Wim PompDivision of Gene Regulation, the Netherlands Cancer Institute, Oncode Institute, 1066CX Amsterdam, Netherlands.ORCID 0000-0002-7623-2073
Karen MeaburnGenome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.
Tiegh TaylorDepartment of Cell and Systems Biology, University of Toronto, Toronto, Ontario M55 3G5, Canada.
Virlana M ShchukaDepartment of Cell and Systems Biology, University of Toronto, Toronto, Ontario M55 3G5, Canada.ORCID 0000-0003-1083-4888
Silvia KocanovaMolecular Cellular and Developmental Biology Unit (MCD), Centre de Biologie Integrative (CBI), University of Toulouse Paul Sabatier, CNRS, 31062 Toulouse, France.
Mariia NazarovaDepartment of Functional Genomics and Cancer, Institute of Genetics and Molecular and Cellular Biology (IGBMC), UMR7104, Centre National de la Recherche Scientifique, U1258, Institut National de la Santé et de la Recherche Médicale, University of Strasbourg, 6704 Illkirch, France.ORCID 0000-0001-5293-4161
Guilherme Monteiro OliveiraDepartment of Functional Genomics and Cancer, Institute of Genetics and Molecular and Cellular Biology (IGBMC), UMR7104, Centre National de la Recherche Scientifique, U1258, Institut National de la Santé et de la Recherche Médicale, University of Strasbourg, 6704 Illkirch, France.ORCID 0000-0002-1945-0517
Jennifer A MitchellDepartment of Cell and Systems Biology, University of Toronto, Toronto, Ontario M55 3G5, Canada.ORCID 0000-0002-7147-4604
Evi SoutoglouGenome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.
Tineke L LenstraDivision of Gene Regulation, the Netherlands Cancer Institute, Oncode Institute, 1066CX Amsterdam, Netherlands.ORCID 0000-0002-4440-9962
Nacho MolinaDepartment of Functional Genomics and Cancer, Institute of Genetics and Molecular and Cellular Biology (IGBMC), UMR7104, Centre National de la Recherche Scientifique, U1258, Institut National de la Santé et de la Recherche Médicale, University of Strasbourg, 6704 Illkirch, France.ORCID 0000-0003-0233-3055
Argyris PapantonisTranslational Epigenetics Group, Institute of Pathology, University Medical Centre Göttingen, Göttingen, Germany.ORCID 0000-0001-7551-1073
Kerstin BystrickyMolecular Cellular and Developmental Biology Unit (MCD), Centre de Biologie Integrative (CBI), University of Toulouse Paul Sabatier, CNRS, 31062 Toulouse, France.
Tom SextonDepartment of Functional Genomics and Cancer, Institute of Genetics and Molecular and Cellular Biology (IGBMC), UMR7104, Centre National de la Recherche Scientifique, U1258, Institut National de la Santé et de la Recherche Médicale, University of Strasbourg, 6704 Illkirch, France.ORCID 0000-0002-7824-1846
Funding
Computational approaches for comparative regulatory genomics to decipher long-range gene regulationR01HG010045 · NHGRI · UNIVERSITY OF WISCONSIN-MADISON · PI ROY, SUSHMITA · 2018 to 2021
$1.4MNHGRI NIH HHS R01 HG010045
Abstract
The spatiotemporal configuration of genes with distal regulatory elements is believed to be crucial for transcriptional control, but full mechanistic understanding is lacking. We combine simultaneous live tracking of pairs of genomic loci and nascent transcripts with molecular dynamics simulations to assess the
Indexed as
Enhancer Elements, GeneticPromoter Regions, GeneticTranscription, GeneticCCCTC-Binding FactorCell Cycle ProteinsChromatinChromosomal Proteins, Non-HistoneCohesinsGene Expression RegulationHumansMolecular Dynamics SimulationSOXB1 Transcription FactorsCCCTC-Binding FactorCell Cycle ProteinsChromatinChromosomal Proteins, Non-HistoneCohesinsSOXB1 Transcription Factors
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.