ArticleScience advances2024
Assembly and biological functions of metal-biomolecule network nanoparticles formed by metal-phosphonate coordination.
Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Assembly of Bioactive Superstructures via Metal-Phenolic Complexation for Blood Purification.Angewandte Chemie (International ed. in English) · 2026Article
- Coordination-Driven Metal-Phenolic Network Complexes for Programmable Colorimetric Signal Transduction and Defined Nano-Bio Interfaces.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Hybrid Ammonium-M(II) Hydrogenophosphite Hydrates as Bioactive Metal Complexes: Synthesis, DFT and Hirshfeld Surface Analysis, and Anticancer and Anti-Inflammatory Activities.Pharmaceuticals (Basel, Switzerland) · 2026Article
- ATP-fueled STING activation of manganese coordinated nanoagonist to boost antitumor immunity.Bioactive materials · 2026Article
- Overcoming barriers: mechanisms and strategies of nanoparticles in overcoming the blood-brain barrier and drug resistance in glioblastomas.Journal of the Egyptian National Cancer Institute · 2026Review
- Biomimetic metal-drug coordination nanoplatform to counteract drug resistance in Pseudomonas aeruginosa via energy disruption.Nature communications · 2026Article
- Plain DNA and cationic aromatics: a platform to simplify carrier-free delivery systems.Journal of nanobiotechnology · 2025Article
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Authors and funding
7 authors.
Funding
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Abstract
Metal-organic networks have attracted widespread interest owing to their hybrid physicochemical properties. Natural biomolecules represent attractive building blocks for these materials because of their inherent biological function and high biocompatibility; however, assembling them into coordination network materials, especially nanoparticles (NPs), is challenging. Herein, we exploit the coordination between metal ions and phosphonate groups, which are present in many biomolecules, to form metal-biomolecule network (MBN) NPs in aqueous solution at room temperature. Various phosphonate-containing biomolecules, including plant phytate, DNA, and proteins, were used to assemble MBN NPs with tunable physicochemical properties (e.g., size). In addition to excellent biocompatibility and high cargo-loading efficiency (>95%), these two-component MBN NPs have various biological functionalities, including endosomal escape, immune regulation, and molecular recognition, thus offering advantages over nonbiomolecular-based coordination materials. This work expands our understanding of metal-organic chemistry with the emerging class of metal-biomolecule systems and provides a pathway for incorporating biofunctionalities into advanced coordination materials for diverse fields.
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Registered trials
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