Evidence map›Paper›PMID 39671482›Full record

ArticleScience advances2024

Effect of pandemic influenza A virus PB1 genes of avian origin on viral RNA polymerase activity and pathogenicity.

Stephanie L Williams, Li Qi, Zong-Mei Sheng, Yongli Xiao, Ashley Freeman, Lex Matthews, Sharon Fong Legaspi, Ervin Fodor, Jeffery K Taubenberger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Innate immune role of IL-6 in influenza a virus pathogenesis.Frontiers in cellular and infection microbiology · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Stephanie L WilliamsViral Pathogenesis and Evolution Section, Laboratory of Infectious Disease, National Institutes of Health, National Institute for Allergy and Infectious Diseases, Bethesda, MD, USA.ORCID 0000-0001-6174-5418
Li QiViral Pathogenesis and Evolution Section, Laboratory of Infectious Disease, National Institutes of Health, National Institute for Allergy and Infectious Diseases, Bethesda, MD, USA.ORCID 0000-0001-6473-8117
Zong-Mei ShengViral Pathogenesis and Evolution Section, Laboratory of Infectious Disease, National Institutes of Health, National Institute for Allergy and Infectious Diseases, Bethesda, MD, USA.ORCID 0000-0003-1946-9215
Yongli XiaoViral Pathogenesis and Evolution Section, Laboratory of Infectious Disease, National Institutes of Health, National Institute for Allergy and Infectious Diseases, Bethesda, MD, USA.
Ashley FreemanViral Pathogenesis and Evolution Section, Laboratory of Infectious Disease, National Institutes of Health, National Institute for Allergy and Infectious Diseases, Bethesda, MD, USA.ORCID 0000-0002-3292-8319
Lex MatthewsViral Pathogenesis and Evolution Section, Laboratory of Infectious Disease, National Institutes of Health, National Institute for Allergy and Infectious Diseases, Bethesda, MD, USA.ORCID 0000-0001-8637-3614
Sharon Fong LegaspiViral Pathogenesis and Evolution Section, Laboratory of Infectious Disease, National Institutes of Health, National Institute for Allergy and Infectious Diseases, Bethesda, MD, USA.ORCID 0000-0003-4111-0057
Ervin FodorSir William Dunn School of Pathology, University of Oxford, Oxford, UK.ORCID 0000-0003-3249-196X
Jeffery K TaubenbergerViral Pathogenesis and Evolution Section, Laboratory of Infectious Disease, National Institutes of Health, National Institute for Allergy and Infectious Diseases, Bethesda, MD, USA.ORCID 0000-0002-9694-7228

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zoonotic influenza A virus (IAV) infections pose a substantial threat to global health. The influenza RNA-dependent RNA polymerase (RdRp) comprises the PB2, PB1, and PA proteins. Of the last four pandemic IAVs, three featured avian-origin PB1 genes. Prior research linked these avian PB1 genes to increased viral fitness when reassorted with human IAV genes. This study evaluated chimeric RdRps with PB1 genes from the 1918, 1957, and 1968 pandemic IAVs in a low pathogenic avian influenza (LPAI) virus background to assess polymerase activity and pathogenicity. Substituting in the pandemic PB1 genes reduced polymerase activity, virulence, and altered lung pathology, while the native LPAI PB1 showed the highest pathogenicity and polymerase activity. The native LPAI PB1 virus caused severe pneumonia and high early viral RNA levels, correlating with elevated host cytokine signaling. Increased genetic distance from the LPAI PB1 sequence correlated with reduced polymerase activity, IFN-β expression, viral replication, and pathogenicity.

Indexed as

Influenza A virusViral ProteinsVirus ReplicationAnimalsBirdsHumansInfluenza, HumanInfluenza in BirdsMicePandemicsRNA-Dependent RNA PolymeraseVirulenceinfluenza virus polymerase basic protein 1RNA-Dependent RNA PolymeraseViral Proteins

Identifiers

PMID39671482
PMCPMC11641000

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.