Evidence map›Paper›PMID 39671241›Full record

ArticleeLife2024

Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings.

Shek Man Chim, Kristen Howell, John Dronzek, Weizhen Wu, Cristopher Van Hout, Manuel A R Ferreira, Bin Ye, Alexander Li, Susannah Brydges, Vinayagam Arunachalam and 17 more

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Synergistic effects ofFrontiers in nutrition · 2026
    Article
  3. Jiangtang Decoction for Type 2 Diabetes and NAFLD: Integrative AnalysisEndocrine, metabolic & immune disorders drug targets · 2026
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Shek Man ChimRegeneron Genetics Center, New York, United States.ORCID https://orcid.org/0000-0002-5116-8394
Kristen HowellRegeneron Genetics Center, New York, United States.
John DronzekRegeneron Genetics Center, New York, United States.
Weizhen WuRegeneron Genetics Center, New York, United States.
Cristopher Van HoutRegeneron Genetics Center, New York, United States.
Manuel A R FerreiraRegeneron Genetics Center, New York, United States.
Bin YeRegeneron Genetics Center, New York, United States.
Alexander LiRegeneron Genetics Center, New York, United States.
Susannah BrydgesRegeneron Pharmaceuticals, New York, United States.
Vinayagam ArunachalamRegeneron Genetics Center, New York, United States.
Anthony MarckettaRegeneron Genetics Center, New York, United States.
Adam E LockeRegeneron Genetics Center, New York, United States.ORCID https://orcid.org/0000-0001-6227-198X
Jonas BovijnRegeneron Genetics Center, New York, United States.
Niek VerweijRegeneron Genetics Center, New York, United States.
Tanima DeRegeneron Genetics Center, New York, United States.
Luca LottaRegeneron Genetics Center, New York, United States.
Lyndon MitnaulRegeneron Genetics Center, New York, United States.
Michelle LeBlancRegeneron Genetics Center, New York, United States.
Regeneron Genetics CenterRegeneron Genetics Center, New York, United States.
David J CareyGeisinger Health System, Danville, United States.
Olle MelanderDepartment of Clinical Sciences, Malmö, Sweden.
Alan ShuldinerRegeneron Genetics Center, New York, United States.
Katia KaralisRegeneron Genetics Center, New York, United States.
Aris N EconomidesRegeneron Genetics Center, New York, United States.ORCID https://orcid.org/0000-0002-6508-8942
Harikiran NistalaRegeneron Genetics Center, New York, United States.ORCID https://orcid.org/0000-0003-4928-7527
DiscovEHR collaboration
Regeneron Genetics Center

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies have revealed a role for zinc in insulin secretion and glucose homeostasis. Randomized placebo-controlled zinc supplementation trials have demonstrated improved glycemic traits in patients with type II diabetes (T2D). Moreover, rare loss-of-function variants in the zinc efflux transporter

Indexed as

Cation Transport ProteinsHyperglycemiaLiverObesityZincAnimalsDiabetes Mellitus, Type 2FemaleHumansMaleMiceMice, Inbred C57BLMice, KnockoutCation Transport ProteinsZincgeneticsgenomicshumanmouseNAFLDType II diabeteszinc transporter

Identifiers

PMID39671241
PMCPMC11648992

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.