Evidence map›Paper›PMID 39671233›Full record

ArticleeLife2024

Estradiol elicits distinct firing patterns in arcuate nucleus kisspeptin neurons of females through altering ion channel conductances.

Jian Qiu, Margaritis Voliotis, Martha A Bosch, Xiao Feng Li, Larry S Zweifel, Krasimira Tsaneva-Atanasova, Kevin T O'Byrne, Oline K Rønnekleiv, Martin J Kelly

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Estrogen Alleviates Sevoflurane-Induced Neurotoxicity by Inhibiting ERα-Tau Binding.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  6. Neuronal plasticity at puberty in mouse hypothalamicProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jian QiuDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, United States.ORCID https://orcid.org/0000-0002-4988-8587
Margaritis VoliotisDepartment of Mathematics and Statistics, University of Exeter, Exeter, United Kingdom.ORCID https://orcid.org/0000-0001-6488-7198
Martha A BoschDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, United States.
Xiao Feng LiDepartment of Women and Children's Health, School of Life Course and Population Sciences, King's College London, London, United Kingdom.
Larry S ZweifelDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, United States.ORCID https://orcid.org/0000-0003-3465-5331
Krasimira Tsaneva-AtanasovaDepartment of Mathematics and Statistics, University of Exeter, Exeter, United Kingdom.ORCID https://orcid.org/0000-0002-6294-7051
Kevin T O'ByrneDepartment of Women and Children's Health, School of Life Course and Population Sciences, King's College London, London, United Kingdom.ORCID https://orcid.org/0000-0002-2548-4182
Oline K RønnekleivDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, United States.ORCID https://orcid.org/0000-0003-1841-4386
Martin J KellyDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, United States.ORCID https://orcid.org/0000-0002-8633-2510

Funding

University of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI Charles Chavkin · 2019 to 2026
$13.0M
Sex Differences in the Control of FeedingR01DK068098 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI KELLY, MARTIN JEFFREY, RØNNEKLEIV, OLINE KARIN · 2005 to 2024
$7.1M
Phasic Dopamine and Symptom Domains of Mental IllnessR01MH104450 · NIMH · UNIVERSITY OF WASHINGTON · PI LARRY S ZWEIFEL · 2015 to 2026
$5.5M
Identification of the Neuroprotective STX Receptor in the BrainR21AG080057 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KELLY, MARTIN JEFFREY, SCHULTZ, CARSTEN · 2023 to 2024
$424k
Biotechnology and Biological Sciences Research Council BB/W005883/1Biotechnology and Biological Sciences Research Council International Partnership Award BB/3019978/1Engineering and Physical Sciences Research Council EP/T017856/1NIA NIH HHS R21 AG080057NIDA NIH HHS P30 DA048736NIDDK NIH HHS R01 DK068098NIH HHS P30-MH048736NIH HHS R01-DK68098NIH HHS R01-MH104450NIMH NIH HHS R01 MH104450
6 · The paper itself

Abstract

Hypothalamic kisspeptin (Kiss1) neurons are vital for pubertal development and reproduction. Arcuate nucleus Kiss1 (Kiss1

Indexed as

Arcuate Nucleus of HypothalamusEstradiolKisspeptinsNeuronsAnimalsDynorphinsFemaleGonadotropin-Releasing HormoneIon ChannelsMiceNeurokinin BVesicular Glutamate Transport Protein 2DynorphinsEstradiolGonadotropin-Releasing HormoneIon ChannelsKiss1 protein, mouseKisspeptinsNeurokinin BVesicular Glutamate Transport Protein 217beta-estradiolburst firingcomputational biologyion channelskisspeptin neuronmathematical modelingmouseneurosciencesynchronous firingsystems biology

Identifiers

PMID39671233
PMCPMC11643640

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.