Evidence map›Paper›PMID 39671133›Full record

ReviewMetabolic brain disease2024

Intricate mechanism of anxiety disorder, recognizing the potential role of gut microbiota and therapeutic interventions.

Sudarshan Singh Lakhawat, Priyanka Mech, Akhilesh Kumar, Naveen Malik, Vikram Kumar, Vinay Sharma, Jasvinder Singh Bhatti, Sunil Jaswal, Sunil Kumar, Pushpender Kumar Sharma

Abstract readReview
PubMed Publisher
In one paragraph

Review in Metabolic brain disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sudarshan Singh LakhawatAmity Institute of Biotechnology, Amity University Rajasthan, SP-1, Kant Kalwar, RIICO Industrial Area, NH-11C, Jaipur, Rajasthan, 303002, India.ORCID 0000-0003-1246-4024
Priyanka MechAmity Institute of Biotechnology, Amity University Rajasthan, SP-1, Kant Kalwar, RIICO Industrial Area, NH-11C, Jaipur, Rajasthan, 303002, India.ORCID 0009-0005-3681-1352
Akhilesh KumarAmity Institute of Biotechnology, Amity University Rajasthan, SP-1, Kant Kalwar, RIICO Industrial Area, NH-11C, Jaipur, Rajasthan, 303002, India.ORCID 0009-0006-1883-3264
Naveen MalikAmity Institute of Biotechnology, Amity University Rajasthan, SP-1, Kant Kalwar, RIICO Industrial Area, NH-11C, Jaipur, Rajasthan, 303002, India.ORCID 0000-0001-6055-8602
Vikram KumarAmity Institute of Pharmacy, Amity University Rajasthan, SP-1, Kant Kalwar, RIICO Industrial Area, NH-11C, Jaipur, Rajasthan, India.ORCID 0000-0002-9994-8904
Vinay SharmaAmity Institute of Biotechnology, Amity University Rajasthan, SP-1, Kant Kalwar, RIICO Industrial Area, NH-11C, Jaipur, Rajasthan, 303002, India.ORCID 0000-0002-8834-702X
Jasvinder Singh BhattiDepartment of Environmental Sciences, Himachal Pradesh University, Summer Hill, Shimla, 171005, India.ORCID 0000-0001-5480-2584
Sunil JaswalDepartment of Human Genetics and Molecular Medicine Central University Punjab, Bathinda, 151401, India.ORCID 0000-0001-8560-592X
Sunil KumarAmity Institute of Biotechnology, Amity University Rajasthan, SP-1, Kant Kalwar, RIICO Industrial Area, NH-11C, Jaipur, Rajasthan, 303002, India.ORCID 0009-0005-9690-5166
Pushpender Kumar SharmaAmity Institute of Biotechnology, Amity University Rajasthan, SP-1, Kant Kalwar, RIICO Industrial Area, NH-11C, Jaipur, Rajasthan, 303002, India. pksharma@jpr.amity.edu.ORCID 0000-0003-0359-744X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anxiety is a widespread psychological disorder affecting both humans and animals. It is a typical stress reaction; however, its longer persistence can cause severe health disorders affecting the day-to-day life activities of individuals. An intriguing facet of the anxiety-related disorder can be addressed better by investigating the role of neurotransmitters in regulating emotions, provoking anxiety, analyzing the cross-talks between neurotransmitters, and, most importantly, identifying the biomarkers of the anxiety. Recent years have witnessed the potential role of the gut microbiota in human health and disorders, including anxiety. Animal models are commonly used to study anxiety disorder as they offer a simpler and more controlled environment than humans. Ultimately, developing new strategies for diagnosing and treating anxiety is of paramount interest to medical scientists. Altogether, this review article shall highlight the intricate mechanisms of anxiety while emphasizing the emerging role of gut microbiota in regulating metabolic pathways through various interaction networks in the host. In addition, the review will foster information about the therapeutic interventions of the anxiety and related disorder.

Indexed as

Anxiety DisordersGastrointestinal MicrobiomeAnimalsBrain-Gut AxisHumansButyrateDepressionGlucocorticoidsMetabolic interaction

Identifiers

PMID39671133

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.