Evidence map›Paper›PMID 39671065›Full record

ArticleDigestive diseases and sciences2025

Linked Color Imaging with Light-Emitting Diode Light Enhances the Visibility of Gastric Neoplasm: A Prospective, Multicenter, Comparative Trial.

Naoto Iwai, Osamu Dohi, Takahiro Kotachi, Momoko Tsuda, Nobuaki Yagi, Shoko Ono, Mayuko Seya, Hajime Teshima, Kimitoshi Kubo, Yuki Nakahata and 5 more

Abstract readMulticenter StudyComparative Study
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In one paragraph

Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Naoto IwaiMolecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kawaramachi Hirokoji Kamigyo-ku, Kyoto, 602-8566, Japan.
Osamu DohiMolecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kawaramachi Hirokoji Kamigyo-ku, Kyoto, 602-8566, Japan. osamu-d@koto.kpu-m.ac.jp.
Takahiro KotachiDepartment of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan.
Momoko TsudaDepartment of Gastroenterology, National Hospital Organization Hakodate National Hospital, Hakodate, Japan.
Nobuaki YagiDepartment of Gastroenterology, Asahi University Hospital, Gifu, Japan.
Shoko OnoDepartment of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Mayuko SeyaMolecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kawaramachi Hirokoji Kamigyo-ku, Kyoto, 602-8566, Japan.
Hajime TeshimaDepartment of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan.
Kimitoshi KuboDepartment of Gastroenterology, National Hospital Organization Hakodate National Hospital, Hakodate, Japan.
Yuki NakahataDepartment of Gastroenterology, Asahi University Hospital, Gifu, Japan.
Akihiro OboraDepartment of Gastroenterology, Asahi University Hospital, Gifu, Japan.
Shiro OkaDepartment of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan.
Shinji TanakaJA Onomichi General Hospital, Onomichi, Japan.
Yoshito ItohMolecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kawaramachi Hirokoji Kamigyo-ku, Kyoto, 602-8566, Japan.
Mototsugu KatoDepartment of Gastroenterology, National Hospital Organization Hakodate National Hospital, Hakodate, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEarly detection of gastric cancer can play a key role in improving prognosis. Recently, light-emitting diodes (LED) have been developed as novel endoscopic systems. However, the differences in the visibility of gastric neoplastic lesions between LED and laser endoscopy remains unclear. We conducted a prospective multicenter trial to evaluate the non-inferiority of LED endoscopy in the visibility of gastric neoplastic lesions undergoing endoscopic submucosal dissection (ESD) in comparison to laser endoscopy.

methodsA multicenter, prospective, cross-sectional study was conducted in patients undergoing ESD for gastric neoplastic lesions at five hospitals throughout Japan. Seventy patients with 74 lesions were included in this study. The primary endpoint was the non-inferiority of the difference in the individual scores of linked color imaging (LCI) and white-light imaging (WLI) for LED and laser endoscopy for gastric neoplastic lesions.

resultsThe mean individual score was 2.66 ± 1.02, 3.17 ± 0.83, 2.75 ± 1.05, and 3.21 ± 0.84 in LED-WLI, LED-LCI, laser-WLI, and laser-LCI, respectively. The difference in individual scores of LCI and WLI was 0.51 ± 0.77 and 0.46 ± 0.80 in LED and laser endoscopy, respectively. The mean difference between LED and laser endoscopy was 0.04 (95% confidence interval [CI]: - 0.05 to 0.13, P < 0.001).

conclusionsThis study revealed the non-inferiority of the differences in individual scores between LCI and WLI in the comparison of LED and laser endoscopy for gastric neoplastic lesions.

Indexed as

Endoscopic Mucosal ResectionGastroscopyStomach NeoplasmsAgedAged, 80 and overColorCross-Sectional StudiesFemaleHumansJapanLightMaleMiddle AgedProspective StudiesGastric neoplastic lesionImage-enhanced endoscopyLaser endoscopyLight-emitting diode endoscopyLinked color imaging

Identifiers

PMID39671065

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.