ArticleDigestive diseases and sciences2025
Integration of Non-invasive Screening for Cystic Fibrosis Related Liver Disease in the Regular Follow-Up for Cystic Fibrosis.
Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Treatment with CFTR Modulators for Cystic Fibrosis: What a Pediatric Gastroenterologist Needs to Know.Children (Basel, Switzerland) · 2025Review
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6 authors.
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Abstract
backgroundThe reported prevalence of cystic fibrosis (CF)-related liver disease (CFLD) reaches up to 40% in some cohorts. CFLD is the 3rd leading cause of mortality among patients with CF. The aims of this study were to evaluate the prevalence of CFLD in a cohort followed at a tertiary university center, to define the types of liver involvement, and to determine how non-invasive screening methods can be optimally integrated into clinical practice.
methodsThe files of patients followed at the CF clinic of the Centre hospitalier de l'Université de Montréal (CHUM) between 2020 and 2022 were retrospectively reviewed. The NIH criteria were used to define CFLD through the presence of one major criterion (abnormal imaging) or two minor criteria (persistently abnormal laboratory values, hepatosplenomegaly, or transient elastography (TE) ≥ 7 kPa).
resultsA total of 357 patients were included in this study. CFLD was observed in 46 patients (13%). Among these, major criteria led to diagnosis in 43 patients (with or without minor criteria). TE performed best in non-invasive assessment of CLFD (area under the curve (AUROC) 0.80 (0.68-0.92, p = 0.0007)). A nodular liver was detected in 27 patients (7%), and was associated with higher non-invasive markers of fibrosis. In addition, presence of a nodular liver was associated with significant short-term mortality (14.8% vs. 1.5%, p = 0.003).
conclusionEarly recognition of CFLD in clinical care can potentially prevent complications of cirrhosis and portal hypertension. The use of abdominal imaging and TE seems promising for detecting CFLD.
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