Evidence map›Paper›PMID 39671002›Full record

SynthesisEuropean journal of pediatrics2024

Zinc sulfate on neonatal hyperbilirubinemia: an updated systematic review and meta-analysis.

Helen Michaela de Oliveira, Mariano Gallo Ruelas, Lucas Mendes Barbosa, Camilo André Viana Diaz, Gustavo Roberto Minetto Wegner, Bruno Francisco Minetto Wegner, André Vieira da Cruz

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in European journal of pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Helen Michaela de OliveiraDepartment of Medicine, Federal University of Mato Grosso, Sinop, Mato Grosso, Brazil. helen.oliveira@sou.ufmt.br.
Mariano Gallo RuelasInstituto de Investigación Nutricional (IIN), Lima, Peru.
Lucas Mendes BarbosaDepartment of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Camilo André Viana DiazDepartment of Medicine, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.
Gustavo Roberto Minetto WegnerDepartment of Medicine, Federal University of Fronteira Sul, Chapecó, Santa Catarina, Brazil.
Bruno Francisco Minetto WegnerDepartment of Medicine, Federal University of Rio Grande Do Sul, Porto Alegre, Rio Grande Do Sul, Brazil.
André Vieira da CruzFederal University of Mato Grosso, Professor of Pediatrics, Sinop, Mato Grosso, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonatal hyperbilirubinemia is a prevalent condition, with a risk of serious complications. Phototherapy is the standard treatment for significant cases, but its limitations highlight the need for additional options. Zinc sulfate has emerged as a potential adjunctive treatment. Our objective is to evaluate the efficacy of zinc sulfate as an adjunct to phototherapy in neonates with hyperbilirubinemia. PubMed, Embase, and CENTRAL were searched for studies published up to September 2024. Eligible studies were randomized clinical trials (RCTs) enrolling neonates with hyperbilirubinemia that evaluated the combined use of phototherapy and zinc sulfate. This study followed PRISMA guidelines, with independent extraction of data by two reviewers. Risk of bias was assessed using the RoB2 tool, and the quality of evidence was evaluated using the GRADE approach. Eleven RCTs comprising 1,349 neonates were included. A total of 690 (51.1%) neonates received zinc sulfate. Zinc sulfate significantly reduced bilirubin levels at 24 h (MD = -0.76 mg/dL; 95% CI = -1.30 to -0.22; P < .01; I

Indexed as

Hyperbilirubinemia, NeonatalPhototherapyZinc SulfateBilirubinCombined Modality TherapyHumansInfant, NewbornRandomized Controlled Trials as TopicBilirubinZinc SulfateHyperbilirubinemiaNeonatesPhototherapyZinc sulfate

Identifiers

PMID39671002

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.