Evidence map›Paper›PMID 39670832›Full record

ArticleACS macro letters2025

Impact of Guest Orientation in Host-Guest Supramolecular Hydrogels.

Christopher J Addonizio, Adam S Braegelman, Connor R Schmidt, Rachel C Ollier, Akwasi Ansah Antwi, Bo Su, Mohsen Farshad, Jonathan K Whitmer, Matthew J Webber

Abstract read
In one paragraph

Article in ACS macro letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Redox- and Photo-Responsive FeACS applied materials & interfaces · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christopher J AddonizioDepartment of Chemical & Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Adam S BraegelmanDepartment of Chemical & Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Connor R SchmidtDepartment of Chemical & Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID 0000-0002-6514-8757
Rachel C OllierDepartment of Chemical & Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID 0000-0003-3549-0436
Akwasi Ansah AntwiDepartment of Chemical & Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Bo SuDepartment of Chemical & Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Mohsen FarshadDepartment of Chemical & Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID 0000-0001-5095-4361
Jonathan K WhitmerDepartment of Chemical & Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID 0000-0003-0370-0873
Matthew J WebberDepartment of Chemical & Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID 0000-0003-3111-6228

Funding

Non-Covalent Molecular Recognition for Drug Targeting in the BodyR35GM137987 · NIGMS · UNIVERSITY OF NOTRE DAME · PI WEBBER, MATTHEW · 2020 to 2024
$2.2M
NIGMS NIH HHS R35 GM137987
6 · The paper itself

Abstract

Host-guest interactions have been increasingly explored for use in the dynamic physical cross-linking of polymeric precursors to form hydrogel networks. However, the orientation of guest motifs is restricted upon macromolecule conjugation. The implications of such restriction on both the kinetics and thermodynamics of the resulting host-guest supramolecular cross-links are poorly understood. Herein, guest cross-linking motifs from controlled regioisomers are demonstrated to yield distinct material properties. Moreover, the underlying phenomena point to a further unexpected impact of modular guest topology on the molecular scale in both the affinity and dynamics of supramolecular complex formation.

Identifiers

PMID39670832
PMCPMC12664294

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.