Evidence map›Paper›PMID 39670709›Full record

ArticleInfection and immunity2025

Novel broadly reactive monoclonal antibody protects against

Margalida Mateu-Borrás, Spencer R Dublin, Jason Kang, Hunter L Monroe, Emel Sen-Kilic, Sarah J Miller, William T Witt, Joshua A Chapman, Gage M Pyles, Shreeram C Nallar and 12 more

Abstract read
In one paragraph

Article in Infection and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Monoclonal Antibodies Targeting Bacterial Infections: A Broad Review of the Field.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  2. Review
  3. Antibodies toMicroorganisms · 2026
    Article
  4. EPY001, a Novel Monoclonal Antibody AgainstInternational journal of molecular sciences · 2025
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Margalida Mateu-BorrásDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, West Virginia, USA.ORCID 0000-0002-6761-9663
Spencer R DublinDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, West Virginia, USA.ORCID 0000-0001-6669-1519
Jason KangDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, West Virginia, USA.ORCID 0000-0001-5736-0005
Hunter L MonroeDepartment of Pathology, Anatomy, and Laboratory Medicine, West Virginia University, Morgantown, West Virginia, USA.
Emel Sen-KilicDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, West Virginia, USA.
Sarah J MillerDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, West Virginia, USA.
William T WittDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, West Virginia, USA.
Joshua A ChapmanDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, West Virginia, USA.
Gage M PylesDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, West Virginia, USA.
Shreeram C NallarSchool of Medicine, Division of Vaccine Research, Institute of Human Virology, University of Maryland Baltimore, Baltimore, Maryland, USA.
Annalisa B HuckabyDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, West Virginia, USA.
Evita YangDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, West Virginia, USA.
Carleena Rocuskie-MarkerDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, West Virginia, USA.
Megan E GrundDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, West Virginia, USA.
Md Shahrier AminDepartment of Pathology, Anatomy, and Laboratory Medicine, West Virginia University, Morgantown, West Virginia, USA.
Slawomir LukomskiDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, West Virginia, USA.ORCID 0000-0002-5159-1838
Greg A SnyderSchool of Medicine, Division of Vaccine Research, Institute of Human Virology, University of Maryland Baltimore, Baltimore, Maryland, USA.
Krishanu RaySchool of Medicine, Division of Vaccine Research, Institute of Human Virology, University of Maryland Baltimore, Baltimore, Maryland, USA.
George K LewisSchool of Medicine, Division of Vaccine Research, Institute of Human Virology, University of Maryland Baltimore, Baltimore, Maryland, USA.
Darrell O RickeLincoln Laboratory, MIT, Lexington, Massachusetts, USA.
F Heath DamronDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, West Virginia, USA.ORCID 0000-0002-3140-402X
Mariette BarbierDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, West Virginia, USA.ORCID 0000-0002-3250-3636

Funding

DOD | Defense Threat Reduction Agency (DTRA) HDTRA12110001Vaccine Development Center, West Virginia University HEPC.dsr.18.6
6 · The paper itself

Abstract

The incidence of infections attributed to antimicrobial-resistant (AMR) pathogens has increased exponentially over the recent decades reaching 1.27 million deaths worldwide in 2019. Without intervention, these infections are predicted to cause up to 10 million deaths a year and incur costs of up to 100 trillion US dollars globally by 2050. The emergence of AMR bacteria such as the ESKAPEE pathogens, and in particular

Indexed as

Antibodies, BacterialAntibodies, MonoclonalPseudomonas aeruginosaPseudomonas InfectionsAnimalsDisease Models, AnimalFemaleFlagellinHumansMiceMice, Inbred BALB CPhagocytosisAntibodies, BacterialAntibodies, MonoclonalFlagellinanti-microbial resistanceBurkholderiamonoclonal antibodiesPseudomonas aeruginosa

Identifiers

PMID39670709
PMCPMC11784295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.