Evidence map›Paper›PMID 39670643›Full record

ArticleJournal of medicinal chemistry2024

A Putative Frizzled 7-Targeting Compound Acts as a Firefly Luciferase Inhibitor.

Julia Kinsolving, Lukas Grätz, Jan Hendrik Voss, Bente Löw, Emily Shorter, Baptiste Jude, Johanna T Lanner, Stefan Löber, Peter Gmeiner, Gunnar Schulte

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julia KinsolvingSection of Receptor Biology & Signaling, Dept. Physiology & Pharmacology, Karolinska Institutet, Stockholm S-171 77, Sweden.
Lukas GrätzSection of Receptor Biology & Signaling, Dept. Physiology & Pharmacology, Karolinska Institutet, Stockholm S-171 77, Sweden.ORCID 0000-0001-6755-0742
Jan Hendrik VossSection of Receptor Biology & Signaling, Dept. Physiology & Pharmacology, Karolinska Institutet, Stockholm S-171 77, Sweden.ORCID 0000-0003-0595-4607
Bente LöwDepartment of Chemistry and Pharmacy, Friedrich-Alexander-Universität, Erlangen 91058, Germany.ORCID 0009-0006-0046-2944
Emily Shorter
Baptiste Jude
Johanna T Lanner
Stefan LöberDepartment of Chemistry and Pharmacy, Friedrich-Alexander-Universität, Erlangen 91058, Germany.
Peter GmeinerDepartment of Chemistry and Pharmacy, Friedrich-Alexander-Universität, Erlangen 91058, Germany.ORCID 0000-0002-4127-197X
Gunnar SchulteSection of Receptor Biology & Signaling, Dept. Physiology & Pharmacology, Karolinska Institutet, Stockholm S-171 77, Sweden.ORCID 0000-0002-2700-7013

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Frizzled family (FZD

Indexed as

Frizzled ReceptorsLuciferases, FireflyWnt Signaling PathwayAnimalsHEK293 CellsHumansMolecular Docking SimulationStructure-Activity RelationshipFrizzled ReceptorsFZD7 protein, humanLuciferases, Firefly

Identifiers

PMID39670643
PMCPMC11684006

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.