ArticlePlant biotechnology journal2025
TmCOP1-TmHY5 module-mediated blue light signal promotes chicoric acid biosynthesis in Taraxacum mongolicum.
Article in Plant biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- Integrated transcriptomic and metabolomic analysis unveils biosynthetic mechanisms of key bioactive isoflavonoid accumulation inHorticulture research · 2026Article
- Genome-Wide Characterization and Light-Responsive Expression Patterns of B-Box Transcription Factors inPlants (Basel, Switzerland) · 2026Article
- Genome-Wide Identification and Analysis of BAHD Acyltransferases Involved in Anthocyanin Biosynthesis inBiology · 2026Article
- Effect of ultrasonic-assisted hot-air drying on the quality and drying kinetics of Taraxacum mongolicum.Ultrasonics sonochemistry · 2026Article
- GeARF5/GeIAA33-GeSWEET14 module balances the secondary metabolic biosynthesis to increase the yield and quality in Gastrodia elata.Journal of integrative plant biology · 2026Article
- Rosmarinic Acid Synthase 1 Phosphorylation by SmMAPK3 Is Required for Salicylic Acid-Induced Salvianolic Acid Accumulation in Salvia miltiorrhiza Hairy Roots.Plant biotechnology journal · 2026Article
- Blue light as an eco-elicitor effectively enhances flavonoid biosynthesis and antioxidant capacity in dandelion revealed by integrated metabolomic and transcriptomic analyses.BMC plant biology · 2026Article
- Identification of theFrontiers in plant science · 2026Article
- GePIF4 Increases the Multi-Flower/Capsule-Bearing Traits and Gastrodin Biosynthesis inPlants (Basel, Switzerland) · 2025Article
- Identification and characterization of the TmSnRK2 family proteins related to chicoric acid biosynthesis in Taraxacum mongolicum.BMC genomics · 2025Article
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11 authors.
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Abstract
Chicoric acid, a phenolic compound derived from plants, exhibits a range of pharmacological activities. Light significantly influences the chicoric acid biosynthesis in Taraxacum mongolicum; however, the transcriptional regulatory network governing this process remains unclear. A combined analysis of the metabolome and transcriptome revealed that blue light markedly enhances chicoric acid accumulation compared to red light. The blue light-sensitive transcription factor ELONGATED HYPOCOTYL5 (HY5) is closely associated with multiple core proteins, transcription factors and chicoric acid synthase genes involved in light signalling. Both in vivo and in vitro experiments demonstrated that TmHY5 directly regulates several chicoric acid biosynthetic genes, including TmPAL3, Tm4CL1 and TmHQT2. Additionally, TmHY5 promotes the accumulation of luteolin and anthocyanins by increasing the expression of TmCHS2 and TmANS2. The E3 ubiquitin ligase CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) forms a protein complex with TmHY5, significantly inhibiting chicoric acid biosynthesis. Blue light inhibits TmCOP1-TmHY5 complex protein formation while enhancing the expression levels of TmCOP1 through TmHY5. Furthermore, TmHY5 elevates the expression levels of TmbZIP1, which indirectly activates Tm4CL1 expression. In vivo, TmCOP1 directly inhibits the expression of the TmHY5-Tm4CL1 complex. Therefore, we speculate that TmCOP1-TmHY5-mediated blue light signalling effectively activates chicoric acid biosynthesis, providing a foundation for the application of blue light supplementation technology in industrial production.
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