ArticleHippocampus2025
Pursuing Synaptic Plasticity From Cortex to LTP in the Hippocampus.
Article in Hippocampus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Principal Components Analysis Relates Hippocampal Trisynaptic Circuit to Vividness of Visual Mental Imagery.Brain and behavior · 2026Article
- The Quest for the Associative Device for Hebbian-Like LTP-The Accidental Participant.Hippocampus · 2026Review
- Life, the Hippocampus, and Everything.Hippocampus · 2026Article
- Glutamate Receptors and Synaptic Plasticity in Health and Disease: A Personal Journey.Hippocampus · 2026Review
- Notes on the History of In Vitro Hippocampal Electrophysiology and LTP: Personal Reflections.Hippocampus · 2025Review
- Development of the SPEAR Model: Separate Phases of Encoding and Retrieval Are Necessary for Storing Multiple Overlapping Associative Memories.Hippocampus · 2025Review
- Long-Term Potentiation: The Accidental Discovery.Hippocampus · 2025Review
- From British Associationism to the Hippocampal Cognitive Map: A Personal View From a Ringside Seat at the Cognitive/PDP Revolution.Hippocampus · 2025Review
- Towards an Understanding of the Dentate Gyrus Hilus.Hippocampus · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here I describe how an interest in synaptic plasticity took me from a PhD at McGill, where I worked on activity-dependent plasticity in the responses of single units in the association cortex of anesthetized cats, to a collaboration with Terje Lømo in Per Andersen's laboratory in Oslo in 1968-9. There we followed up on Lømo's discovery of LTP, published as an abstract in 1966, to produce the first detailed description of the phenomenon. Later, in London, Tony Gardner-Medwin and I showed that LTP lasting for days could be obtained in the awake rabbit. The two papers were published together in the Journal of Physiology in 1973. I relate how difficulties in replicating our results in English rabbits, and the failure of the first attempts to obtain LTP in slices of the dentate gyrus, led to my abandoning work on LTP for a few years, returning to the fray in the late 1970s through a collaboration with Graham Goddard at Dalhousie University in Halifax, Canada.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.