Evidence map›Paper›PMID 39670335›Full record

ArticleClinical and translational science2024

Real-world evidence in the cloud: Tutorial on developing an end-to-end data and analytics pipeline using Amazon Web Services resources.

Wes Anderson, Roopal Bhatnagar, Keith Scollick, Marco Schito, Ramona Walls, Jagdeep T Podichetty

Abstract read
In one paragraph

Article in Clinical and translational science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wes AndersonCritical Path Institute, Tucson, Arizona, USA.
Roopal BhatnagarCritical Path Institute, Tucson, Arizona, USA.
Keith ScollickCritical Path Institute, Tucson, Arizona, USA.
Marco SchitoCritical Path Institute, Tucson, Arizona, USA.
Ramona WallsCritical Path Institute, Tucson, Arizona, USA.
Jagdeep T PodichettyCritical Path Institute, Tucson, Arizona, USA.ORCID 0009-0001-3922-3549

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the rapidly evolving landscape of healthcare and drug development, the ability to efficiently collect, process, and analyze large volumes of real-world data (RWD) is critical for advancing drug development. This article provides a blueprint for establishing an end-to-end data and analytics pipeline in a cloud-based environment. The pipeline presented here includes four major components, including data ingestion, transformation, visualization, and analytics, each supported by a suite of Amazon Web Services (AWS) tools. The pipeline is exemplified through the CURE ID platform, a collaborative tool designed to capture and analyze real-world, off-label treatment administrations. By using services such as AWS Lambda, Amazon Relational Database Service (RDS), Amazon QuickSight, and Amazon SageMaker, the pipeline facilitates the ingestion of diverse data sources, the transformation of raw data into structured formats, the creation of interactive dashboards for data visualization, and the application of advanced machine learning models for data analytics. The described architecture not only supports the needs of the CURE ID platform, but also offers a scalable and adaptable framework that can be applied across various domains to enhance data-driven decision making beyond drug repurposing.

Indexed as

Cloud ComputingDatabases, FactualDrug DevelopmentHumansInternetMachine LearningSoftware

Identifiers

PMID39670335
PMCPMC11638732

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.