Evidence map›Paper›PMID 39670180›Full record

ReviewJournal of tissue engineering

Bioinspired synthetic peptide-based biomaterials regenerate bone through biomimicking of extracellular matrix.

Sareh Azadi, Mohammad Ali Yazdanpanah, Ali Afshari, Niloofar Alahdad, Solmaz Chegeni, Abdolhamid Angaji, Seyed Mahdi Rezayat, Shima Tavakol

Abstract readReview
In one paragraph

Review in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sareh AzadiDepartment of Medical Biotechnology, Iran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-9876-1419
Mohammad Ali YazdanpanahDepartment of Cell and Molecular Biology, Faculty of Biological Science, Kharazmi University, Tehran, Iran.
Ali AfshariDepartment of Cell and Molecular Biology, Faculty of Biological Science, Kharazmi University, Tehran, Iran.
Niloofar AlahdadDepartment of Cell and Molecular Biology, Faculty of Biological Science, Kharazmi University, Tehran, Iran.
Solmaz ChegeniCellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Abdolhamid AngajiDepartment of Medical Biotechnology, Iran University of Medical Sciences, Tehran, Iran.
Seyed Mahdi RezayatDepartment of Medical Nanotechnology, Tehran University of Medical Sciences, Tehran, Iran.
Shima TavakolCellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-8531-7650

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There have been remarkable advancements in regenerative medicine for bone regeneration, tackling the worldwide health concern of tissue loss. Tissue engineering uses the body's natural capabilities and applies biomaterials and bioactive molecules to replace damaged or lost tissues and restore their functionality. While synthetic ceramics have overcome some challenges associated with allografts and xenografts, they still need essential growth factors and biomolecules. Combining ceramics and bioactive molecules, such as peptides derived from biological motifs of vital proteins, is the most effective approach to achieve optimal bone regeneration. These bioactive peptides induce various cellular processes and modify scaffold properties by mimicking the function of natural osteogenic, angiogenic and antibacterial biomolecules. The present review aims to consolidate the latest and most pertinent information on the advancements in bioactive peptides, including angiogenic, osteogenic, antimicrobial, and self-assembling peptide nanofibers for bone tissue regeneration, elucidating their biological effects and potential clinical implications.

Indexed as

angiogenesisantimicrobial peptidesbioactive peptidebiological motifsBone regeneration

Identifiers

PMID39670180
PMCPMC11635874

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.