ArticleJournal of oral and maxillofacial pathology : JOMFP
Quantitative correlation of serum and salivary trace elements in oral squamous cell carcinoma and oral potentially malignant disorders: An institution-based biochemical analysis.
Article in Journal of oral and maxillofacial pathology : JOMFP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Fundamental characteristics of voltage-modulated helium plasma for multi-element analysis in low-volume samples.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Article
- Biosensors in dental, oral and craniofacial applications.Npj biosensing · 2026Review
- Biological copper levels in oral squamous cell carcinoma: A meta-analysis with insights into disease progression and prognosis.Journal of oral biology and craniofacial researchReview
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Authors and funding
6 authors.
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Abstract
Background: Trace elements are the important components that play a crucial role in various functions of the human body at cellular and molecular levels. Considering the role of the trace elements in precancerous and cancerous conditions, estimation of their levels in these conditions could aid in understanding the disease process and progression. The purpose of this study is to determine the alteration in salivary electrolyte concentration of oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC) patients to correlate the variations with the severity and biological behaviour. Material and Method: A total of 70 subjects were included in this study, and they were divided into three groups: patients with OSCC (30), OPMDs (30) and apparently healthy individuals (10). An informed consent was obtained, following which blood and saliva samples were collected from the participants. Salivary and serum levels of copper, zinc, lead, cadmium, calcium and magnesium were measured and compared between the groups. Results: The levels of biochemical elements in both serum and saliva were in perfect correlation. The amount of all the estimated metallic ions was found to be significantly ( Conclusion: Salivary trace element levels could possibly have diagnostic significance in the early evaluation of OPMDs and OSCC as well. Increased levels of these elements might be used as a marker of disease progression and predictor of prognosis.
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