ArticleEnvironmental epidemiology (Philadelphia, Pa.)2025
Life-course exposure to air pollution and the risk of dementia in the Lothian Birth Cohort 1936.
Article in Environmental epidemiology (Philadelphia, Pa.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Airborne pollutants and risk of neurodegenerative diseases: a global systematic review and meta-analysis.Alzheimer's research & therapy · 2026Pooled it
- Long-term exposure to ambient particulate matter and its association with Alzheimer's disease: influencing factors and a systematic review with meta-analysis.Frontiers in public health · 2026Pooled it
- Environmental Pollution, Biomarkers, and Dementia: An Evidence Review.International journal of molecular sciences · 2026Review
- State Policy Liberalism in Adolescence and Risk for Dementia from 2000 to 2016 among Older U.S. Adults.Journal of health and social behavior · 2026Article
- Modeling approaches for estimating the effects of risk factors using longitudinal lifecourse exposure data in dementia research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- A bibliometric and systematic review of the global impact of air pollution on Alzheimer's disease: Insights from cohort studies.Journal of Alzheimer's disease reportsReview
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Air pollution in later life has been associated with dementia; however, limited research has investigated the association between air pollution across the life course, either at specific life periods or cumulatively. The project investigates the association of air pollution with dementia via a life-course epidemiological approach. Methods: Participants of the Lothian Birth Cohort, born in 1936, provided lifetime residential history in 2014. Participant's air pollution exposure for time periods 1935, 1950, 1970, 1980, 1990, 2001, and 2007 was modeled using an atmospheric chemistry transport model. Lifetime cumulative exposures were calculated as time-weighted mean exposure. Of 572 participants, 67 developed all-cause dementia [35 with Alzheimer's dementia (AD)] by wave 5 (~82 years). Cox proportional hazards and competing risk models assessed the association between all-cause dementia and AD with particulate matter (diameter of ≤2.5 µm) PM Results: The mean follow-up was 11.26 years. One standard deviation (SD) higher exposure to air pollution in 1935 (PM Conclusion: The in-utero and early-life exposure to PM
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