ArticleiScience2024
Perceptual learning and neural correlates of virtual navigation in subjective cognitive decline: A pilot study.
Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Digital neuroplasticity modulation of the brain-immune axis: Translational strategies for neurodegenerative, psychiatric, and aging-related conditions.Neural regeneration research · 2026Article
- Local and global microstructural and functional thalamomotor connectivity alterations in Parkinson's disease following motor learning.NPJ Parkinson's disease · 2026Article
- Neural correlates of Parkinson's improvements after combined digital-levodopa therapy: a pilot study.Brain communications · 2026Article
- Mobile application leads to psychological improvement and correlated neuroimmune function change in subjective cognitive decline.NPJ digital medicine · 2025Article
- Brain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spatial navigation deficits in age-related diseases involve brain changes affecting spatial memory and verbal cognition. Studies in blind and blindfolded individuals show that multisensory training can induce neuroplasticity through visual cortex recruitment. This proof-of-concept study introduces a digital navigation training protocol, integrating egocentric and allocentric strategies with multisensory stimulation and visual masking to enhance spatial cognition and brain connectivity in 17 individuals (mean age 57.2 years) with subjective cognitive decline. Results indicate improved spatial memory performance correlated with recruitment of the visual area 6-thalamic pathway and enhanced connectivity between memory, executive frontal areas, and default mode network (DMN) regions. Additionally, increased connectivity between allocentric and egocentric navigation areas via the retrosplenial complex (RSC) hub was observed. These findings suggest that this training has the potential to induce perceptual learning and neuroplasticity through key functional connectivity hubs, offering potential widespread cognitive benefits by enhancing critical brain network functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.