Evidence map›Paper›PMID 39669426›Full record

ArticleiScience2024

Cytosolic bacterial pathogens activate TLR pathways in tumors that synergistically enhance STING agonist cancer therapies.

Meggie Danielson, Christopher J Nicolai, Thaomy T Vo, Natalie K Wolf, Thomas P Burke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Transforming bacterial pathogens into wonder tools in cancer immunotherapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Meggie DanielsonMicrobiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92617, USA.
Christopher J NicolaiMolecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Thaomy T VoMicrobiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92617, USA.
Natalie K WolfMolecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Thomas P BurkeMicrobiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92617, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracellular bacterial pathogens are distinctive tools for fighting cancer, as they can proliferate in tumors and deliver therapeutic payloads to the eukaryotic cytosol. Cytosol-dwelling bacteria have undergone extensive preclinical and clinical testing, yet the mechanisms of activating innate immunity in tumors are unclear. We report that phylogenetically distinct cytosolic pathogens, including

Indexed as

Health sciencesMolecular biologyMolecular mechanism of gene regulation

Identifiers

PMID39669426
PMCPMC11635009

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.