ArticleOpen research Europe2023
Parametrizing analog multi-compartment neurons with genetic algorithms.
Article in Open research Europe, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Parametrizing analog multi-compartment neurons with genetic algorithms.Open research Europe · 2023Article
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5 authors.
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Abstract
Background: Finding appropriate model parameters for multi-compartmental neuron models can be challenging. Parameters such as the leak and axial conductance are not always directly derivable from neuron observations but are crucial for replicating desired observations. The objective of this study is to replicate the attenuation behavior of an excitatory postsynaptic potential (EPSP) traveling along a linear chain of compartments on the analog BrainScaleS-2 neuromorphic hardware platform. Methods: In the present publication we use genetic algorithms to find suitable model parameters. They promise parameterization without domain knowledge of the neuromorphic substrate or underlying neuron model. To validate the results of the genetic algorithms, a comprehensive grid search was conducted. Furthermore, trial-to-trial variations in the analog system are counteracted utilizing spike-triggered averaging. Results and conclusions: The algorithm successfully replicated the desired EPSP attenuation behavior in both single and multi-objective searches illustrating the applicability of genetic algorithms to parameterize analog neuromorphic hardware.
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