ArticleThe Lancet regional health. Europe2024
Platelet transfusion in neonatal intensive care units of 22 European countries: a prospective observational study.
Article in The Lancet regional health. Europe, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Optimizing platelet transfusion thresholds in preterm infants: a systematic review and narrative synthesis of impacts on survival and neurodevelopment.Blood transfusion = Trasfusione del sanguePooled it
- The specifications of blood components for neonatal transfusion: a European study and critical review.Pediatric research · 2026Article
- Blood loss due to diagnostic testing in extremely preterm infants in 22 European countries: a prospective observational study.EClinicalMedicine · 2026Article
- Anesthesia Practices for Preterm Infants: A Survey in the Nordic Countries and Review of the Literature.Acta anaesthesiologica Scandinavica · 2026Review
- The whole is greater than the sum of its parts: Rethinking our approach to neonatal transfusion research.Transfusion · 2025Review
- Observational
- Plasma transfusions in neonatal intensive care units: a prospective observational study.Archives of disease in childhood. Fetal and neonatal edition · 2025Observational
- How bureaucracy is bleeding science dry: international observational research under the General Data Protection Regulation.The Lancet regional health. Europe · 2025Article
Corrections and comments
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Authors and funding
33 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Platelet transfusions are given to preterm infants with severe thrombocytopenia aiming to prevent haemorrhage. The PlaNeT2/MATISSE trial revealed higher rates of mortality and/or major bleeding in preterm infants receiving prophylactic platelet transfusions at a platelet count threshold of 50 × 10 Methods: We performed a prospective observational study in 64 neonatal intensive care units across 22 European countries between September 2022 and August 2023. Outcome measures included observed transfusion prevalence rates (per country and overall, pooled using a random effects Poisson model), expected rates based on patient-mix (per country, estimated using logistic regression), cumulative incidence of receiving a transfusion by day 28 (with death and discharge considered as competing events), transfusion indications, volumes and infusion rates, platelet count triggers and increment, and adverse effects. Findings: We included 1143 preterm infants, of whom 71 (6.2%, [71/1143]) collectively received 217 transfusions. Overall observed prevalence rate was 0.3 platelet transfusion days per 100 admission days. By day 28, 8.3% (95% CI: 5.5-11.1) of infants received a transfusion. Most transfusions were indicated for threshold (74.2%, [161/217]). Pre-transfusion platelet counts were above 25 × 10 Interpretation: The restrictive threshold of 25 × 10 Funding: Sanquin, EBA, and ESPR.
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