Evidence map›Paper›PMID 39669223›Full record

ArticleIBRO neuroscience reports2024

Valproic acid attenuates the severity of astrogliosis in the hippocampus of animal models of temporal lobe epilepsy.

Hu Feng, Jiamin Luo, Zhiwei Li, Yuxiao Zhao, Yamei Liu, Hongyan Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IBRO neuroscience reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hu FengSchool of Life Sciences, Shanghai University, Nanchen Road 333, Shanghai 200436, China.
Jiamin LuoSchool of Life Sciences, Shanghai University, Nanchen Road 333, Shanghai 200436, China.
Zhiwei LiSchool of Life Sciences, Shanghai University, Nanchen Road 333, Shanghai 200436, China.
Yuxiao ZhaoSchool of Life Sciences, Shanghai University, Nanchen Road 333, Shanghai 200436, China.
Yamei LiuSchool of Life Sciences, Shanghai University, Nanchen Road 333, Shanghai 200436, China.
Hongyan ZhuSchool of Life Sciences, Shanghai University, Nanchen Road 333, Shanghai 200436, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reactive astrogliosis is one of the most frequency neuropathological alterations in the hippocampus of animal models and patients with temporal lobe epilepsy (TLE). Valproic acid (VPA), a widely used antiepileptic drug (AED), acts by blocking ion channels and enhancing GABAergic activity. This study investigated the effects of VPA on hippocampal astrogliosis in a rat model of TLE. The results demonstrated that chronic administration of VPA at a dose of 200 mg/kg significantly reduced the severity of astrogliosis and ameliorated neuronal loss in the hippocampus at the early and middle stages post-status epilepticus (SE), while also improving cognitive impairments at the middle and late stages in KA-SE rats. Long-term administration of VPA at 400 mg/kg attenuated astrogliosis in the hippocampus at the middle stage post-SE, but lacked neuroprotective effects and exacerbated cognitive impairments at the late stage. These findings suggest that VPA at an appropriate dose could mitigate hippocampal astrogliosis, potentially offering a new antiepileptic mechanism for its long-term use.

Indexed as

Neuronal lossReactive astrogliosisTemporal lobe epilepsyValproic acid

Identifiers

PMID39669223
PMCPMC11635005

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.