Development and characterization of gastro-floating sustained-release granules for enhanced bioavailability of patchouli oil.

Chen Liu, Yanan Wu, Yeli Zou, Jiao Wang, Boli Li, Yanni Ma, Xia Zhang, Wenping Wang

Abstract read

In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Chen LiuGeneral Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China.

Yanan WuCollege of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.

Yeli ZouCollege of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.

Jiao WangCollege of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, Yunnan, 650500, China.

Boli LiCollege of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.

Yanni MaGeneral Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China.

Xia ZhangCollege of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.

Wenping WangCollege of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, Yunnan, 650500, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patchouli oil (PO), extracted from Methods: The oil-laden granules were prepared using colloidal silicon dioxide (CSD) for oil adsorption and to provide buoyancy, along with ethyl cellulose (EC) and hydroxypropyl methyl cellulose (HPMC) to form a sustained-release matrix. The CSD exhibited favorable characteristics for oil adsorption and floating. Compatibility between PO and CSD was affirmed through DSC thermograms and FTIR spectra. The obtained granules demonstrated a sustained release profile, achieving over 90 % release within 10 h without an initial burst. After oral administration, the granules were observed to remain in the gastric region of rats for over 7 h. The bioavailability of patchouli alcohol from the optimized granules was significantly higher than that from of the PO-loaded powders. The gastro-floating sustained-release granules, based on a CSD/EC/HPMC matrix, offer a simple yet effective strategy to improve the delivery efficacy of PO against

Indexed as

AdsorptionBioavailabilityColloidal silicon dioxideGastroretentive granulesPatchouli oilSustained release

Identifiers

PMID39669168

DOI10.1016/j.heliyon.2024.e40374

PMCPMC11635734

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.