ArticleHepatobiliary surgery and nutrition2024
Comparative analysis of analgesic efficacy and functional recovery in open pancreaticoduodenectomy: a randomized controlled trial of local anesthetic wound infiltration, transversus abdominis plane block, and intramuscular electrical stimulation.
Article in Hepatobiliary surgery and nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Comparison of the efficiency of ultrasound-guided ESPB and TAPB on postoperative analgesia: a system review and meta-analysis.Frontiers in medicine · 2025Pooled it
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Pancreaticoduodenectomy (PD) is associated with severe postoperative pain. Optimized pain management can potentially elevate patients' postoperative quality of life. This study focused on comparing the analgesic efficacy and subsequent functional recovery of three techniques, continuous local wound infiltration (LWI), four-quadrant transversus abdominis plane (4QTAP) block, and needle electrical twitch obtaining intramuscular stimulation (NETOIMS), in patients subjected to open PD. Methods: This is a prospective, single-blinded, randomized controlled study. Among a total of 80 eligible patients, 72 were randomized into the LWI, 4QTAP block, or NETOIMS groups for postoperative pain management. The primary outcome measured was the pain score, which was recorded on postoperative days (PODs) 0, 1, 2, 3, 5, 7, 14, and 28. Additionally, consumption of morphine milligram equivalents (MMEs) and ibuprofen until POD 3 was analyzed. Functional recovery indicators, such as gait speed and peak cough flow (PCF), were assessed on the day before surgery (baseline), and on PODs 2, 7, 14, and 28. A one-way analysis of variance, with subsequent Results: Out of the 72 patients, 68 (LWI, 22; 4QTAP, 23; NETOIMS 23) were included in the final analysis. Compared to the LWI group, both the 4QTAP block and NETOIMS group demonstrated significantly lower pain scores from PODs 0 through 7 (P<0.001 for POD 0-5; P=0.001 for POD 7, for both groups). The pain scores in the 4QTAP block and NETOIMS groups were comparable across all recorded time points. Up to POD 3, there was a significant reduction in both MMEs (P<0.001) and ibuprofen consumption (P=0.003) in these groups. Additionally, on POD 2, the 4QTAP block and NETOIMS groups exhibited superior PCF (P<0.001) and faster gait speed (P=0.008) compared to the LWI group. Conclusions: Compared to LWI, both 4QTAP block and NETOIMS were more effective in reducing postoperative pain, necessitated fewer analgesics, and facilitated improved functional recovery after PD. Trial Registration: Clinical Research Information Service of Korea Disease Control and Prevention Agency; cris.nih.go.kr; registration ID: KCT0005814.
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