Evidence map›Paper›PMID 39668762›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2024

An outbreak of influenza A(H1N1)pdm09 antigenic variants exhibiting cross-resistance to oseltamivir and peramivir in an elementary school in Japan, September 2024.

Emi Takashita, Kohei Shimizu, Shuzo Usuku, Ryuichi Senda, Ichiro Okubo, Hiroko Morita, Shiho Nagata, Seiichiro Fujisaki, Hideka Miura, Noriko Kishida and 7 more

Abstract read
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Emi TakashitaResearch Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Tokyo, Japan.
Kohei ShimizuYokohama City Institute of Public Health, Kanagawa, Japan.
Shuzo UsukuYokohama City Institute of Public Health, Kanagawa, Japan.
Ryuichi SendaYokohama City Institute of Public Health, Kanagawa, Japan.
Ichiro OkuboYokohama City Institute of Public Health, Kanagawa, Japan.
Hiroko MoritaResearch Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Tokyo, Japan.
Shiho NagataResearch Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Tokyo, Japan.
Seiichiro FujisakiResearch Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Tokyo, Japan.
Hideka MiuraResearch Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Tokyo, Japan.
Noriko KishidaResearch Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Tokyo, Japan.
Kazuya NakamuraResearch Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Tokyo, Japan.
Masayuki ShirakuraResearch Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Tokyo, Japan.
Masataka IchikawaIchikawa Children's Clinic, Kanagawa, Japan.
Yoko MatsuzakiYamagata University Faculty of Medicine, Yamagata, Japan.
Shinji WatanabeResearch Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Tokyo, Japan.
Yoshimasa TakahashiResearch Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo, Japan.
Hideki HasegawaResearch Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An outbreak of influenza A(H1N1)pdm09 viruses exhibiting cross-resistance to oseltamivir and peramivir occurred in Yokohama, Japan, in September 2024. Among 24 students in a class, 11 were diagnosed with influenza or influenza-like illness, and viruses harbouring the NA H275Y and HA Q210H substitutions were isolated from four. Deep sequencing analysis confirmed the clonal spread of these mutants. Antigenic analysis revealed differences from the vaccine strain. Continued monitoring is crucial to assess the potential for further spread of these mutant viruses.

Indexed as

Acids, CarbocyclicAntiviral AgentsCyclopentanesDisease OutbreaksDrug Resistance, ViralGuanidinesInfluenza A Virus, H1N1 SubtypeInfluenza, HumanNeuraminidaseOseltamivirChildFemaleHumansJapanMaleMutationAcids, CarbocyclicAntiviral AgentsCyclopentanesGuanidinesNeuraminidaseOseltamivirperamivirantiviralbaloxavirinfluenzaoseltamivirperamivirresistance

Identifiers

PMID39668762
PMCPMC11650510

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.