Evidence map›Paper›PMID 39668712›Full record

ArticleChemMedChem2025

Synthesis of New Enantiopure Aminoalcohol Fluorenes as Promising Antimalarial Compounds.

Camille Tisnerat, Jérémy Schneider, Romain Mustière, Aurélie Herrero, René Momha, Céline Damiani, Patrice Agnamey, Anne Totet, Mathieu Marchivie, Jean Guillon and 2 more

Abstract read
In one paragraph

Article in ChemMedChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Camille TisneratUFR de Pharmacie, Université de Picardie Jules Verne, Amiens, France.ORCID https://orcid.org/0000-0003-4009-725X
Jérémy SchneiderUFR de Pharmacie, Université de Picardie Jules Verne, Amiens, France.
Romain MustièreUFR de Pharmacie, Université de Picardie Jules Verne, Amiens, France.
Aurélie HerreroUFR de Pharmacie, Université de Picardie Jules Verne, Amiens, France.
René MomhaUFR de Pharmacie, Université de Picardie Jules Verne, Amiens, France.
Céline DamianiUFR de Pharmacie, Université de Picardie Jules Verne, Amiens, France.
Patrice AgnameyUFR de Pharmacie, Université de Picardie Jules Verne, Amiens, France.
Anne TotetUFR de Pharmacie, Université de Picardie Jules Verne, Amiens, France.
Mathieu MarchivieUniversité de Bordeaux, CNRS, INP, ICMCB, UMR 5026, Pessac, Bordeaux, F-33600, France.ORCID https://orcid.org/0000-0003-1362-0797
Jean GuillonINSERM U1212, UMR CNRS 5320, Laboratoire ARNA, UFR des Sciences Pharmaceutiques, Université de Bordeaux, Bordeaux, France.ORCID https://orcid.org/0000-0001-8577-3894
Alexandra Dassonville-KlimptUFR de Pharmacie, Université de Picardie Jules Verne, Amiens, France.ORCID https://orcid.org/0000-0002-2891-9102
Pascal SonnetUFR de Pharmacie, Université de Picardie Jules Verne, Amiens, France.ORCID https://orcid.org/0000-0003-0118-9151

Funding

ANR Astrid ANR-23-ASTR-0005Délégation Générale pour l'Armement PDH-2-NRBC-4-4104Région Hauts-de-FranceUniversité d'ArtoisUniversité de Picardie Jules Verne
6 · The paper itself

Abstract

Herein, we report the design, synthesis, and characterisation of a new library of enantiopure aminoalcohol fluorenes, as well as their in vitro evaluation for biological properties, including activity against two strains of P. falciparum (3D7 and W2) and cytotoxicity on the HepG2 cell line. All tested compounds exhibited good to excellent antimalarial potency with IC

Indexed as

Amino AlcoholsAntimalarialsFluorenesPlasmodium falciparumCell SurvivalDose-Response Relationship, DrugHep G2 CellsHumansMolecular StructureParasitic Sensitivity TestsStereoisomerismStructure-Activity RelationshipAmino AlcoholsAntimalarialsFluorenes

Identifiers

PMID39668712
PMCPMC11911300

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.