Evidence map›Paper›PMID 39668463›Full record

ArticleAdvanced healthcare materials2025

Pre-Clinical Assessment of Bupivacaine-Loaded Poly(ester urea) Thin Films for Controlled Drug Release and Effective Pain Management After Surgery.

Natasha C Stinson, Yutaka Matsuoka, Anshu Agarwal, Courtney S Dziewior, Samantha M McDonald, Yize Li, Kacey Godwin, Ru-Rong Ji, Matthew L Becker

Abstract read
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In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Natasha C StinsonDepartment of Chemistry, Duke University, Durham, NC, 27708, USA.
Yutaka MatsuokaCenter for Translational Pain Medicine, Department of Anesthesiology, Duke University, Durham, NC, 27710, USA.
Anshu AgarwalThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, 27708, USA.
Courtney S DziewiorDepartment of Chemistry, Duke University, Durham, NC, 27708, USA.
Samantha M McDonaldDepartment of Chemistry, Duke University, Durham, NC, 27708, USA.
Yize LiCenter for Translational Pain Medicine, Department of Anesthesiology, Duke University, Durham, NC, 27710, USA.
Kacey GodwinDepartment of Chemistry, Duke University, Durham, NC, 27708, USA.
Ru-Rong JiCenter for Translational Pain Medicine, Department of Anesthesiology, Duke University, Durham, NC, 27710, USA.
Matthew L BeckerDepartment of Chemistry, Duke University, Durham, NC, 27708, USA.ORCID 0000-0003-4089-6916

Funding

Non-Opioid Post-Operative Pain Management Using Bupivacaine-loaded Poly(ester urea) MeshR44GM140795 · NIGMS · 21MEDTECH LLC · PI YU, JIAYI · 2021 to 2021
$1.7M
Congressionally Directed Medical Research Programs 8Congressionally Directed Medical Research Programs CDMRP W81XWH-15-1-071Congressionally Directed Medical Research Programs W81XWH-221-06-46Direct to Phase II award led by 21MedTechNIDA NIH HHS 1R44GM140795-01A1NIGMS NIH HHS R44 GM140795Office of the Assistant Secretary of Defense for Health Affairs
6 · The paper itself

Abstract

Safe, effective pain management remains one of the biggest challenges following surgical procedures. Despite widespread recognition of this problem and advances in the mechanistic understanding of pain signaling, post-surgical pain is often undermanaged, with opioid use remaining the clinical standard. As an alternative to current oral, systemic treatments, a degradable bupivacaine-loaded poly(ester urea) (PEU) thin film has been developed to deliver bupivacaine directly to the site of injury over an extended duration. The dose and duration of bupivacaine delivery is controlled using polymer composition and bupivacaine concentration. Systemic bupivacaine concentrations are more than an order of magnitude lower when delivered locally versus intravenous injection. Tissue analysis showed that the majority of bupivacaine is deposited into subcutaneous tissue directly surrounding the implant. Bupivacaine concentration in soft tissue around the implant are 30-fold higher than plasma values, indicating that release from PEU implants remains localized. Bupivacaine-loaded PEU films are assessed into two established mouse models for diabetic neuropathic pain and post-surgical incisional pain. In each model, bupivacaine eluting PEU films effectively block pain for 3-5 days before returning to baseline levels without loss of motor function and without signs of neurotoxicity.

Indexed as

BupivacainePain ManagementPolyestersPostoperative PainUreaAnesthetics, LocalAnimalsDelayed-Action PreparationsDrug LiberationMaleMiceAnesthetics, LocalBupivacaineDelayed-Action PreparationsPolyestersUreabiomaterialsbupivacainedrug deliverypain managementpoly(ester urea)

Identifiers

PMID39668463
PMCPMC11959288

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.